CAS: 2708-77-2; 4-Fluoro-Dl-Glutamic Acid

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173282-21-8 91383-47-0 91383-48-1

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📜γ-Fluoroglutamic Acid Diisopropyl Ester Hydrochloride置于盐酸体系中,化学反应 3.0H,以84%的收率获得4-氟-Dl-谷氨酸
参考文献:Chemistry Of 4-Fluoroglutamic Acid. Part 2. Separation Of The Diastereomers On A Large Scale. Preparation Of Cis-And Trans-4-Fluoro-5-Pyrrolidone-2-Carboxylic Acids (4-Fluoropyroglutamic Acids)
标题:Chemistry Of 4-Fluoroglutamic Acid. Part 2. Separation Of The Diastereomers On A Large Scale. Preparation Of Cis-And Trans-4-Fluoro-5-Pyrrolidone-2-Carboxylic Acids (4-Fluoropyroglutamic Acids)
摘要:Separation Of The 4-Fluoroglutamic Acid Diastereomers Has Been Achieved By Crystallization Of The Hydrochlorides Of Their Dialkyl Esters 1B And 2D. Subsequent Hydrolysis Afforded The Diastereomers 1A And 2A In 100% Steric Purity. Conversion Of The Acids Into The 5-Methyl Esters Followed By Treatment With Ammonia Gives Rise To The Trans And Cis Isomers Of 4-Fluoro-5-Pyrrolidone-2-Carboxylic Acid,3 And 4. NMR Data Are Given.
Doi:10.1016/s0022-1139(00)80033-0

专利信息

专利号:US-12234299-B2
优先权日:2018-11-22
标 题 :Peptides for inducing bacteriocin synthesis and methods to identify and/or select and/or optimize the same
发明人：MIGNOLET JOHANN; HOLS PASCAL; LEDESMA GARCÃ?A LAURA
权利人:SYNGULON S A; UNIV CATHOLIQUE LOUVAIN
摘要:Described herein is a peptide or peptidomimetic with a length of at least 6 residues comprising, consisting essentially of, or consisting of the sequence motif Xaa1-Trp-Xaa2-Xaa3-Xaa4-Xaa5 (SEQ ID NO:1), wherein: Xaa1 represents an aromatic residue (Phe, Tyr, Trp, His), Cys or Ser; Xaa2, Xaa3 and Xaa4 represent any residue; and Xaa5 represents Gly, lie or Val.

专利号:US-9375497-B2
优先权日:2006-11-01
标题:[F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamine, derivatives thereof and use thereof and processes for their preparation
发明人：DINKELBORG LUDGER; FRIEBE MATTHIAS; KRASIKOWA NIKOLAEVNA RAISA; BELOKON YURI; KUZNETSOVA FEDOROVNA OLGA; GRAHAM KEITH; LEHMANN LUTZ; BERNDT MATHIAS
权利人:BAYER SCHERING PHARMA AG; PIRAMAL IMAGING SA
摘要:The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.

专利号:EP-1923382-A1
优先权日:2006-11-18
标 题:[18F] labelled L-glutamic acid, [18F] labelled glutamine, their derivatives, their use and processes for their preparation
发明人：DINKELBORG LUDGER; FRIEBE MATTHIAS; KRASIKOWA RAISA NIKOLAEVNA; BELOKON YURI; KUZNETSOVA OLGA FEDOROVNA; GRAHAM KEITH; LEHMANN LUTZ; BERNDT MATHIAS
权利人:BAYER SCHERING PHARMA AG
摘要:The compounds and the synthesis of [F-18] labeled L-glutamic acid, [F-18] labeled L-glutamate, their derivatives according to formula (I) and their uses are described.