CAS: 2577-90-4; (S)-Methyl 2-Amino-3-Phenylpropanoate

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7524-50-7 13033-84-6 51987-73-6

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CAS号67-56-1 甲醇 | CAS号63-91-2 L-苯丙氨酸 | CAS号64590-81-4 (E)-α-(N-acylam... | CAS号7524-50-7 L-苯丙氨酸甲酯盐酸盐 | CAS号51987-73-6 N-B°C-L-苯丙氨酸甲酯 | CAS号150-30-1 DL-苯丙氨酸 | CAS号2311-21-9 甲酰基-L-苯丙氨酸甲酯 | CAS号106018-94-4 (S)-methyl 3-ph... | CAS号129397-81-5 Fm°C-Phe-°CH3 | CAS号3303-55-7 L-苯丙氨酰-L-亮氨酸 | CAS号2862-51-3 环(L-苯丙氨酰-L-苯丙氨酰) | CAS号3182-95-4 L-苯丙氨醇 | CAS号131288-67-0 (S)-2-氨基-3-环己基-1-丙醇 | CAS号5267-64-1 D-苯丙氨醇 | CAS号346440-54-8 (2S,5S)-5-苄基-2-... | CAS号15080-84-9 H-Phe-Met-OH | CAS号22951-94-6 H-Phe-Ile-OH | CAS号184774-09-2 N,N-Dibenzyl-L-... | CAS号66399-75-5 methyl N-benzyl...

L-苯丙氨酸盐酸盐置于tea体系中,用 四氢呋喃 用作溶剂,化学反应 0.5H,反应生成L-苯丙氨酸甲酯
参考文献:Esterification Of Amino Acids And Mono Acids Using Triphosgene
标题:Esterification Of Amino Acids And Mono Acids Using Triphosgene
摘要:Alkyl Esters Of Several Amino Acids And Acids Were Prepared Using Triphosgene [t Richloromethyl Carbonate,Tpa (2)].
Doi:10.1081/scc-100104468

专利信息

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:US-7193103-B2
优先权日:2000-05-19
标题:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives
发明人：PRAKASH INDRA
权利人:NUTRASWEET CO
摘要:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester.

专利号:US-5554725-A
优先权日:1994-09-14
标题:Synthesis of dolastatin 15
发明人：PETTIT GEORGE R
权利人:UNIV ARIZONA
摘要:The present invention relates to the synthesis of natural (-)- dolastatin and the elucidation of the absolute configuration of this important sea hare constituent. A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15. Reaction of protected (S)-Hiva-(S)-Phe (2c) with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c→3a) of the product in toluene and finally methylation afforded the key (S)-dolapyrrolidine (Dpy) derivative (3b). Condensation of tripeptide (8) with the three unit Dpy segment (5b) followed by deprotection and coupling (diethyl phosphorocyanidate) led to dolastatin 15 in 11% overall yield. The powerful and selective activity of dolastatin 15 against the U.S. National Cancer Institute's panel of human cell lines is reported.

专利号:US-7723539-B2
优先权日:2004-06-16
标题:Catalysts based on metal complexes for the synthesis of optically active chrysanthemic acid
发明人：CARLONI SILVIA; BORZATTA VALERIO; MORONI LENI; TANZI GIADA; SARTORI GIOVANNI; MAGGI RAIMONDO
权利人:ENDURA SPA
摘要:Catalysts are described based on metal complexes derived from optically active s compounds, chosen from the classes consisting of bisoxazolines and salicylaldimines supported on an organic or inorganic matrix and employed in particular for the synthesis of optically active chrysanthemic acid.

专利号:US-7037691-B2
优先权日:2001-07-02
标题:Kinase mimic catalysts for asymmetric synthesis of phosphorylated inositols and cycloalkanols
发明人：MILLER SCOTT J; SCULIMBRENE BIANCA; MORGAN ADAM J
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides peptide-based phosphorylation catalysts (PBPC's) for the asymmetric monophosphorylation of cyclitols, particularly myo-inositols. The PBPC's of the invention effect a regio and enantioselective phosphorylation of a myo-inositol in a manner analogous to enzymatic kinases, thereby functioning as effective “kinase mimics.â€? Although orders of magnitude less complex in terms of structure than macromolecular proteins, the PBPC's of the invention control product formation with high enantioselectivity (>98% ee). The synthetic (+)-myo-inositol-1-phosphate is optically and spectroscopically equivalent to naturally occuring compound. The ability of the low molecular weight PBPC's of the present invention to mimic stereoselective enzymes represents a powerful approach toward catalytic asymmetric synthesis of biologically important molecules, and for mechanistic modeling of biochemical transformations to enable their use in drug applications.

专利号:US-6903181-B2
优先权日:2001-02-06
标 题:Methods of synthesis of polysuccinimide, copolymers of polysuccinimide and derivatives thereof
发明人：SWIFT GRAHAM; REDLICH GEORGE H
权利人:FOLIA INC
摘要:Disclosed are methods of synthesis of polysuccinimide, copolymers and derivatives thereof: also disclosed are methods of forming derivatives by ring-opening initiation reactions.