CAS: 24868-20-0; 1-(((5-(4-Nitrophenyl)Furan-2-yl)Methylene)Amino)Imidazolidine-2,4-Dione, Sodium Salt Hydrate(2:2:7)

专利信息

专利号:US-6413785-B1
优先权日:1998-02-20
标题:Solid phase synthesis of 1-aminohydantoins
发明人：WILSON LAWRENCE JOSEPH; PORTLOCK DAVID EDWARD; LI MIN
权利人:PROCTER & GAMBLE
摘要:The subject invention involves processes for making 1-aminohydantoin compounds using a solid support resin, comprising the following steps; (a) preparing a resin-bound protected α-hydrazinyl ester; (1) by reacting the resin with an α-bromo carboxylic acid, then with a protected hydrazine; or (2) by reacting the resin with a protected α-hydrazinyl carboxylic acid; (b) preparing a resin-bound imine by removing the blocking group from the hydrazinyl moiety, then reacting the unprotected hydrazinyl moiety with an aldehyde or ketone; (c) preparing a resin-bound secondary urea: (1) by reacting the imine with p-nitrophenylchloroformate or trisphosgene, then with a primary amine; or (2) by reacting the imine with an isocyanate, and (d) preparing the 1-aminohydantoin compound by removing the secondary urea from the resin and cyclizing it.

专利号:AU-2181199-A
优先权日:1998-02-20
标 题 :Solid phase synthesis of 1-aminohydantoins

专利号:WO-2013023155-A1
优先权日:2011-08-11
标 题:Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use