CAS: 2041-14-7; (2-Aminoethyl)Phosphonic Acid
该化合物是有机磷酸化合物,具有氨基和磷酸功能组的特征,看起来像是白色晶状固体,在水中可溶解,便于应用于各种用途;化合物的分子式包括碳,氢,氮,氮,氧和磷,反映其氨基酸和磷酸的双重功能;氨基磷酸因其作为生化前体的作用而著称,并参与磷酸和其他衍生物的合成;它具有与金属离子的切合等特性,可以作为植物的生长调节器;此外,还研究了磷酸(2-氨基乙基)在农业,制药和研究中的潜在用途,作为生物化学工具,在各种条件下和与金属形成复杂体的能力稳定,使其在工业和学术环境中都成为关注的化合物;在处理和使用时,应参考安全数据,如同任何化学物质一样,用于处理和使用.
- 英文名称(2-Aminoethyl)Phosphonic Acid
- 中文名称2-氨基乙基膦酸
- IUPAC名称(2-aminoethyl)phosphonic acid
- 其它别名Phosphonicacid, (2-aminoethyl)- (6CI,7CI,8CI,9CI); (2-Aminoethyl)phosphonic acid; 2-Aminoethanephosphonic acid; Ciliatine; Phosphonoethylamine; b-Aminoethylphosphonic acid
- CAS编号2041-14-7
- MFCD编号:MFCD00008182
- EINECS号:218-043-0
- FDA UNII编号:AH00YJQ334
- 分子式:C2H8NO3P
- 分子量:125.06
- 产品CID: 1034914
- 产品分类有机原料→分子砌块→脂肪链类化合物
- 相似结构搜索
- 产品信息参考
;; - InChIKey: QQVDJLLNRSOCEL-UHFFFAOYSA-N
- InChI=1S/C2H8NO3P/c3-1-2-7(4,5)6/h1-3H2,(H2,4,5,6)…
- 计算化学: 氢键受体数2.0氢键供体数3.0可旋转键数2.0
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2-(2-二乙氧基磷酰乙基)异吲哚-1,3-二酮置于盐酸体系中,化学反应生成2-氨基乙基膦酸
参考文献:Cameron,David G.; Hudson,Harry R.; Pianka,Max,Phosphorus,Sulfur And Silicon And The Related Elements,1993,Vol. 83,# 1-4,P. 21-38
标题:Cameron,David G.; Hudson,Harry R.; Pianka,Max,Phosphorus,Sulfur And Silicon And The Related Elements,1993,Vol. 83,# 1-4,P. 21-38
专利信息
专利号:US-5981691-A
优先权日:1997-04-23
标题 :Imide-free and mixed amide/imide thermal synthesis of polyaspartate
发明人：SIKES C STEVEN
权利人:UNIV SOUTH ALABAMA
摘要:Thermal polymerization of a salt of aspartic acid affords polyaspartate directly without hydrolyzing polysuccinimide. Copolymerization of a salt of aspartic acid with aspartic acid itself affords a copolymer of succinimide and aspartate which may be readily derivatized to produce a sulfonated, phosphonated or hydrophobized polymer.
专利号:US-8431745-B2
优先权日:2006-03-29
标题 :Process for preparation of HIV protease inhibitors
发明人：CRAWFORD KENNETH R; DOWDY ERIC D; GUTIERREZ ARNOLD; POLNIASZEK RICHARD P; YU RICHARD HUNG CHIU
权利人:CRAWFORD KENNETH R; DOWDY ERIC D; GUTIERREZ ARNOLD; POLNIASZEK RICHARD P; YU RICHARD HUNG CHIU; GILEAD SCIENCES INC
摘要:A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.
专利号:US-6017700-A
优先权日:1995-08-04
标 题:Cationic oligonucleotides, and related methods of synthesis and use
发明人：HORN THOMAS; LETSINGER ROBERT L; BALASUBRAMANIAM TANJORE N
权利人:BAYER CORP; UNIV NORTHWESTERN
摘要:Novel oligonucleotides are provided having cationic internucleoside linkages. The cationic internucleoside linkage has the structure ##STR1## wherein W, X, Y, Z, R 1 , R 2 , and R 3 are as defined herein, P* represents an asymmetric phosphorus atom capable of existing in two distinct stereoisomeric configurations, and further wherein the internucleoside linkage is stereouniform. Certain of these oligonucleotides may have alternating anionic and cationic internucleoside linkages, which are not necessarily stereouniform. A method for synthesizing the compounds are provided as well, as are methods for using the compounds, e.g., as antisense molecules and in nucleic acid hybridization assays.
专利号:CA-2288179-A1
优先权日:1997-04-23
标 题:Imide-free and mixed amide/imide thermal synthesis of polyaspartate
专利号:US-6140310-A
优先权日:1990-06-13
标题 :Phosphorous prodrugs
发明人：GLAZIER ARNOLD
权利人:DRUG INNOVATION & DESIGN INC
摘要:The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorus bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.
专利号:US-6762174-B1
优先权日:1998-02-24
标题:Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof
发明人：TAUB FLOYD E
权利人:DOVETAIL TECHNOLOGIES INC
摘要:The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.
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主要参考文献
[参考文献]: Alexander D Kim, Et Al. The 2-Aminoethylphosphonate-Specific Transaminase Of The 2-Aminoethylphosphonate Degradation Pathway. J Bacteriol. 2002 Aug;184(15):4134-40.[参考文献]: Celia C H Chen, Et Al. Degradation Pathway Of The Phosphonate Ciliatine: Crystal Structure Of 2-Aminoethylphosphonate Transaminase. Biochemistry. 2002 Nov 5;41(44):13162-9.
[参考文献]: G Vidal, Et Al. Aminomethylphosphonate And 2-Aminoethylphosphonate As (31)P-Nmr Ph Markers For Extracellular And Cytosolic Spaces In The Isolated Perfused Rat Liver. Nmr Biomed. 2000 Aug;13(5):289-96.
[参考文献]: Kinfai Au, Et Al. Structures Of An Alanine Racemase From Bacillus Anthracis (Ba0252) In The Presence And Absence Of (R)-1-Aminoethylphosphonic Acid (L-Ala-P). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):327-33.
[参考文献]: Mitali Sarkar, Et Al. Properties Of Phosphoenolpyruvate Mutase, The First Enzyme In The Aminoethylphosphonate Biosynthetic Pathway In Trypanosoma Cruzi. J Biol Chem. 2003 Jun 20;278(25):22703-8.
合成参考文献
摘要:V. Chavane, Ann. Chim. (Paris) [12], 4, 383 (1949).
参考文献:10.1023/a:1014409929875
摘要:Kononova SV, Nesmeyanova MA. Phosphonates and their degradation by microorganisms. Biochemistry (Mosc). 2002 Feb;67(2):184–95. doi: 10.1023/a:1014409929875.
参考文献:10.1007/s10532-006-9057-7
摘要:Klimek-Ochab M, Obojska A, Picco AM, Lejczak B. Isolation and characterization of two new microbial strains capable of degradation of the naturally occurring organophosphonate - ciliatine. Biodegradation. 2007 Apr;18(2):223–31. doi: 10.1007/s10532-006-9057-7.
参考文献:10.1016/0304-4165(68)90223-7
摘要:La Nauze JM, Rosenberg H. The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus. Biochimica et Biophysica Acta (BBA) - General Subjects. 1968 Oct;165(3):438–47. doi: 10.1016/0304-4165(68)90223-7.
参考文献:10.1038/s41467-021-24482-1
摘要:Wu P, Chen D, Ding W, Wu P, Hou H, Bai Y, Zhou Y, Li K, Xiang S, Liu P, Ju J, Guo E, Liu J, Yang B, Fan J, He L, Sun Z, Feng L, Wang J, Wu T, Wang H, Cheng J, Xing H, Meng Y, Li Y, Zhang Y, Luo H, Xie G, Lan X, Tao Y, Li J, Yuan H, Huang K, Sun W, Qian X, Li Z, Huang M, Ding P, Wang H, Qiu J, Wang F, Wang S, Zhu J, Ding X, Chai C, Liang L, Wang X, Luo L, Sun Y, Yang Y, Zhuang Z, Li T, Tian L, Zhang S, Zhu L, Chang A, Chen L, Wu Y, Ma X, Chen F, Ren Y, Xu X, Liu S, Wang J, Yang H, Wang L, Sun C, Ma D, Jin X, Chen G. The trans-omics landscape of COVID-19. Nature Communications. 2021 Jul 27;12(1):4543. doi: 10.1038/s41467-021-24482-1.
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