CAS: 19078-72-9; 2-Bromo-2-Phenylacetyl Chloride

上下游产品

phenylacetic acid 2-bromophenylacetic acid phenylacetyl chloride 2-(4-bromophenyl)acetyl chloride bromo-phenyl-acetic acid methyl ester ethyl 2-phenyl-2-bromoacetate 2-bromo-2-phenylethanamide α-bromo-benzyl is°Cyanate

📜苯乙酰氯置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈体系中,用 四氯化碳 用作溶剂,化学反应 8.0H,反应生成溴(苯基)乙酰氯
参考文献:神经肽yy 2受体的小分子拮抗剂jnj 31020028的发现与合成
标题:神经肽yy 2受体的小分子拮抗剂jnj 31020028的发现与合成
摘要:合成了一系列基于从我们的化合物库中鉴定出的化学型的小分子,并测试了对人神经肽yy 2受体(npy Y 2)的结合亲和力(ic 50).23个类似物的六测试的所具有的npyý 2 Ic 50 ⩽15Nm以下.该系列的一个成员,Jnj 31020028,是一种外消旋混合物形式的选择性,高亲和力受体拮抗剂.这样,从市售的(S)-(+)-扁桃酸开始设计合成所需对映体的合成途径.
Doi:10.1016/j.Bmcl.2011.06.136

专利信息

专利号:US-5919433-A
优先权日:1996-12-04
标 题:Macrocyclic metal complex carboxylic acids, their use as well as process for their production
发明人：PLATZEK JOHANNES; RADUECHEL BERND; SCHMITT-WILLICH HERIBERT
权利人:SCHERING AG
摘要:The invention relates to new macrocyclic metal complex carboxylic acids of formula II whereby Zo stands for a metal ion equivalent of atomic numbers 58-71 and R stands for a CHX1-CO-NH-CHY1-(CH2)f-COOH group, in which X1 and Y1, independently of one another, mean a hydrogen atom, a straight-chain or branched C1-C7 alkyl radical, a phenyl or benzyl group and f means numbers 0 to 9. They can be used as intermediate stages for synthesis of cascade polymer complexes that are suitable as diagnostic agents.