CAS: 1884461-72-6; (E)-1-(2-(2-(Mesitylimino)-9,10-Dimethoxy-4-Oxo-6,7-Dihydro-2H-Pyrimido[6,1-A]Isoquinolin-3(4H)-yl)Ethyl)Urea
- 英文名称(E)-1-(2-(2-(Mesitylimino)-9,10-Dimethoxy-4-Oxo-6,7-Dihydro-2H-Pyrimido[6,1-A]Isoquinolin-3(4H)-yl)Ethyl)Urea
- 中文名称(E)-1-(2-(2-(均三甲苯基亚氨基)-9,10-二甲氧基-4-氧代-6,7-二氢-2H-A[6,1-A]异喹啉-3(4H)-基)乙基)脲
- IUPAC名称(E)-1-(2-(2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea
- 其它别名4,6-Dimethylisothiazolo[5,4-B]Pyridin-3-Ol; Urea, N-(2-(6,7-Dihydro-9,10-Dimethoxy-4-Oxo-2-((2,4,6-Trimethylphenyl)Imino)-2H-Pyrimido(6,1-A)Isoquinolin-3(4H)-yl)Ethyl)-
- CAS编号1884461-72-6
- EINECS号:973-852-2
- FDA UNII编号:3E3D8T1GIX
- 分子式:C26H31N5O4分子量:477.57
- 产品CID: 956160
- 同类组份化合物CAS3098314-20-3 (tosylate)1884461-72-6 (free base)
- 产品分类Inhibitors/Agonists → Metabolic Enzyme → PDE
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2907210001-间苯二酚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-120004884-A
优先权日:2024-09-18
标题 :Enzefin Synthesis process of statin
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Donohue JF, Rheault T, MacDonald-Berko M, Bengtsson T, Rickard K. Ensifentrine as a Novel, Inhaled Treatment for Patients with COPD. Int J Chron Obstruct Pulmon Dis. 2023 Jul 28;18:1611-1622. doi: 10.2147/COPD.S413436.
2: Stolfa I, Page C. Phosphodiesterase inhibitors and lung diseases. Adv Pharmacol. 2023;98:55-81. doi: 10.1016/bs.apha.2023.05.001. Epub 2023 May 26. 208(4):344-346. doi: 10.1164/rccm.202307-1164ED.
4: Anzueto A, Barjaktarevic IZ, Siler TM, Rheault T, Bengtsson T, Rickard K, Sciurba F. Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease: Randomized, Double-Blind, Placebo-controlled, Multicenter Phase III Trials (the ENHANCE Trials). Am J Respir Crit Care Med. 2023 Aug 15;208(4):406-416. doi: 10.1164/rccm.202306-0944OC.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).
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