CAS: 115029-24-8; 2-Fluoro-4-(Trifluoromethyl)Benzoic Acid

相似化合物

146070-34-0 197239-49-9 89763-93-9

上下游产品

2-chloro-4-(trifluoromethyl)benzoic acid 2-[3-(5-[(2-Fluoro-4-trifluoromethylbenzoyl)-amino]methyl-6-ethoxy-pyridin-3-yl)phenyl]acetic acid H-[1,3,4]oxadiazol-2-one5-(2-fluoro-4-trifluoromethyl-phenyl)-3H-[1,3,4]oxadiazol-2-one 3-[(5-chloro-2-methoxy-phenyl)methyl]-5-[2-fluoro-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one

📜2-氯-4-三氟甲基苯甲酸置于18-冠醚-6,Potassium Fluoride Dihydrate体系中,用 1,3-二噁烷 用作溶剂,以11.8 G的收率获得2-氟-4-三氟甲基苯甲酸
参考文献:一种合成2-氟-4-三氟甲基苯甲酸的方法
标题:一种合成2-氟-4-三氟甲基苯甲酸的方法
摘要:本发明公开了一种合成2‑氟‑4‑三氟甲基苯甲酸的方法.以间氯三氟甲苯原料,与2,2,6,6‑四甲基哌啶氯化镁或2,2,6,6‑四甲基哌啶锂选择性去质子后,通入二氧化碳生成2‑氯‑4‑三氟甲基苯甲酸,接着氟化钾亲核取代后得到2‑氟‑4‑三氟甲基苯甲酸.该方法原料易得,步骤短,反应选择性高,具有潜在的工业化放大前景.

专利信息

专利号:WO-2025077857-A1
优先权日:2023-10-13
标题:Use of prmt5 inhibitor in treatment of tumors or cancers
发明人：YAO BING; GU XIAOHUI; MAO WEIFENG; ASWAD FRED JULLIEN; JOSEPH JAMES DAVID; LI MINGXI
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:The present disclosure describes a novel molecule having protein arginine methyltransferase 5 inhibitory activity, and methods for synthesis and use of a compound. Specifically, the present disclosure describes a compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and methods for synthesis and use of the compound.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-7189749-B2
优先权日:1999-06-25
标 题 :Substituted phenoxyacetic acids
发明人：VAN ZANDT MICHAEL C
权利人:INST FOR PHARM DISCOVERY INC
摘要:Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.