CAS: 10081-67-1; 4,4-Bis(A,A-Dimethylbenzyl)Diphenylamine

相似化合物

2479-47-2 4627-22-9 4496-49-5

上下游产品

diphenylamine isopropenylbenzene 2,4-dimethyl-1-heptene N-phenyl-1-naphthylamine BBTPA bis[4-(2-phenyl-2-isopropyl)phenyl]-4-aminophenylamine bis[4-(2-phenyl-2-isopropyl)phenyl]-4-nitrophenylamine

二苯胺,2-苯基-1-丙烯置于tris(Pentafluorophenyl)Borane Hydrate体系中,用 2,2,2-三氟乙醇,乙腈 用作溶剂,以19 %的收率获得4,4'-二(苯基异丙基)二苯胺
参考文献:H2O ⋅ B(C6F5)3‐catalyzed Para‐alkylation Of Anilines With Alkenes Applied To Late‐stage Functionalization Of Non‐steroidal Anti‐inflammatory Drugs
标题:H2O ⋅ B(C6F5)3‐catalyzed Para‐alkylation Of Anilines With Alkenes Applied To Late‐stage Functionalization Of Non‐steroidal Anti‐inflammatory Drugs
摘要:摘要 苯胺是多种重要分子(包括药物,材料和农用化学品)的核心基团.我们报告了一种简单易行的方法,可通过对位 C-H 烷基化进入苯胺的新化学空间.该方法利用市场上可买到的催化 H2O⋅b(C6F5)3 对苯胺的对位-C-烷基化(优于 N-烷基化和正交-C-烷基化)具有高度选择性,在苯胺底物和烯烃偶联剂方面都有广泛的应用范围.该方法使用了现成的烯烃,并首次使用了新类别的烯烃.由于反应条件温和,该方法可用于非甾体抗炎药(nsaid)的后期功能化,包括非那西酸和双氯芬酸.与母体非甾体抗炎药结构相比,所形成的新型非甾体抗炎药衍生物具有更好的抗炎特性.
Doi:10.1002/chem.202303130

专利信息

专利号:CA-2815198-A1
优先权日:2010-10-20
标题 :Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent

专利号:EP-2630116-A2
优先权日:2010-10-20
标 题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent

专利号:EP-2630116-B1
优先权日:2010-10-20
标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent

专利号:KR-20140020236-A
优先权日:2010-10-20
标题:Synthesis of Methylene Malonate Using Rapid Recovery in the Presence of Heat Transfer Agents

专利号:CN-103502198-A
优先权日:2010-10-20
标 题:Synthesis of methylene malonate using rapid recovery in the presence of heat transfer agents

专利号:CN-103502198-B
优先权日:2010-10-20
标 题 :Synthesis of methylene malonate using rapid recovery in the presence of heat transfer agents