CAS: 958293-79-3; 2-(6-D3-Methoxynaphthalen-2-yl)Propanoic Acid

📜(S)-2-(6-D3-Methoxynaphthalen-2-yl)Propanoic Acid D3-Methyl Ester置于水,Lithium Hydroxide,盐酸体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应 2.0H,以73%的收率获得产物萘普生d3
参考文献: Napthylene Inhibitors Of Cyclooxygenase[fr] Inhibiteurs De Naphtylène De La Cyclo-Oxygénase
标题: Napthylene Inhibitors Of Cyclooxygenase[fr] Inhibiteurs De Naphtylène De La Cyclo-Oxygénase

专利信息

专利号:US-2007276042-A1
优先权日:2006-05-26
标题:Preparation and utility of substituted carboxylic acid compounds
发明人：GANT THOMAS G; SARSHAR SEPEHR; WOO SOON HYUNG
权利人:AUSPEX PHARMACEUTICALS INC
摘要:The present disclosure is directed to modulators of cyclooxygenase (COX) enzymes and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of non-specific pain, tension-type pain, headache, migraine, lower back pain, sciatica, dental pain, muscular pain, pain associated with acute soft tissue injuries, bursitis, tendonitis, lumbago, periarthritis, tennis elbow, sprains, strains, muscular problems associated with sports injuries, muscular problems associated with accidents, period pain, primary dysmenorrhoea, acute sore throat pain, osteoarthritis, rheumatoid arthritis, cancer, any disorder requiring analgesic response, any disorder requiring anti-inflammatory response, any disorder requiring antipyretic response, any conditions mediated by cyclooxygenase, cystic fibrosis, dementia, Alzheimer's disease, and/or conditions mediated by levels of β-amyloid are described.