CAS: 88112-75-8; 4-Bromo-2-Fluorophenylisocyanate
该化合物是一种有机化合物,其特点是存在一种苯环,代之以溴原子,氟原子和异丙氰酸盐功能组;该化合物一般在室温上呈现晶状固体形式,由于异丙烯酸组的可参与核分裂生物学附加反应而闻名其反应;溴和氟原子的存在带来巨大的电子能量差异,影响化合物的化学行为和极性;该化合物经常用于有机合成,并可作为生产药品或农用化学品的一种中间体;在处理该化合物时,安全防范至关重要,因为异丁酸可能对皮肤和呼吸系统有毒和刺激;应当遵循适当的储存和处理程序,以减轻与接触有关的任何健康风险.
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
呼吸道致敏 类别1
皮肤致敏 类别1
严重眼刺激 类别2A - 警示词Warning(警告)
- 危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
H317 |可能引起皮肤过敏反应. - 防范说明P261-P280-P305+P351+P338
- UN编号UN 2206 6.1/PG 3
- 危险品标志Xn
- 安全声明26-36/37/39
- 危险类别码20/21/22-36/37/38
- WGK Germany3.0
欧盟法规
ECHA物质C&L通报上下游产品
4-bromo-2-fluoroaniline trichloromethyl chloroformate phosgene bis(trichloromethyl) carbonate methyl 4-[3-(4-bromo-2-fluorophenyl)-2-oxo-5-oxazolidinyl]methoxybenzoate 3-(4-bromo-2-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 1,1-dimethylethyl (3S)-3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-pyrrolidinecarboxylate 1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate合成工艺路线路线简述
- 合成目标产物 4-Bromo-2-Fluorophenyl Isocyanate 主要起始原料 Triphosgene And 4-Bromo-2-Fluoroaniline
- 367-24-8 = 88112-75-8
反应条件:1.1 Solvents: 1,4-Dioxane; 0 °C; 1 H,Rt; 2 H,Reflux
标题:Synthesis And Structure-Activity Relationship Of 4-Substituted Benzoic Acids And Their Inhibitory Effect On The Biosynthesis Of Fatty Acids And Sterols
作者:Ohno,Tomoyasu; Et Al
参考文献:Archiv Der Pharmazie (Weinheim 日期:2005 卷标:338(4) 页码:147-158]
926045-05-8 = 88112-75-8
反应条件:1.1 Solvents: Toluene; 1 H,15 - 20 °C
标题:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono- And Polyfluorophenyl Series
作者:Lebedev,A. V.; Et Al
参考文献:Russian Journal Of General Chemistry 日期:2006 卷标:76(1) 页码:110-115]
367-24-8 = 88112-75-8
反应条件:1.1 Solvents: Toluene; 1 H,-5 - 0 °C; 2 H,0 °C -> Rt; Rt -> Reflux; Reflux
标题:Syntheses And Cytotoxic Activities Of Imatinib Derivatives
作者:Chen,Shijie; Et Al
参考文献:Huaxue Tongbao 日期:2015 卷标:78(7) 页码:621-626]
367-24-8 = 88112-75-8
反应条件:1.1 Catalysts: Sulfuric Acid; 1 H,170 - 175 °C2.1 Solvents: Toluene; 1 H,15 - 20 °C
标题:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono- And Polyfluorophenyl Series
作者:Lebedev,A. V.; Et Al
参考文献:Russian Journal Of General Chemistry 日期:2006 卷标:76(1) 页码:110-115
📜4-溴-2-氟苯胺置于硫酸体系中,用 甲苯 作为反应溶剂,化学反应 2.0H,反应生成 异氰酸4-溴-2-氟苯酯
参考文献:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
标题:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
摘要:A Convenient Synthesis Of Known And Unknown Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series,Involving Silylation Of Starting Amines With Hexamethyldisilazane Or Chlorotrimethylsilane,Followed By Phosgenation Of The Resulting N-Silyl-Substituted Amines. An Unusual High-Temperature Rearrangement Of 3-(Methoxycarbonyl)-4,5-Dimethylthiophene-2-Yl Isocyanate Into Its 5-Ethyl Isomer. Ortho-Fluorine Substituent In Anilines Decreases The Yield Of Isocyanates,Whereas 2,3,5,6-Tetrafluorophenyl Isocyanate Exists For Only A Short Time As A 5% Toluene Solution.
DOI:10.1134/s1070363206010208
海关参考信息
- 2912110000-甲醛
2929109000-其他异氰酸酯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
