CAS: 869-52-3; Triethylenetetramine-N,N,N',N'',N''',N'''-Hexaacetic Acid

上下游产品

formaldehyd sodium cyanide triethylentetramine diethyl 3,6,9,12-tetrakis(2-ethoxy-2-oxoethyl)-3,6,9,12-tetraazatetradecanedioate

📜Diethyl 3,6,9,12-Tetrakis(2-Ethoxy-2-Oxoethyl)-3,6,9,12-Tetraazatetradecanedioate置于水,Sodium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 12.0H,以72.3%的收率获得产物三乙烯四胺六乙酸
参考文献:피부 외피용 조성물
标题:피부 외피용 조성물
摘要:本发明提供一种皮肤外用组合物,其以选择自下述化学式1所示的三烯烃或三烯烃衍生物,自下述化学式2所示的环戊烯或环戊烯衍生物,以及自下述化学式3所示的环己烯或环己烯衍生物中选择的一种或多种作为有效成分.[化学式1] [化学式2] [化学式3](在上述式中,R,R,R,R,R和r分别独立地表示氢,-R-Cooh或其盐,R表示c-C的脂肪族,取代或未取代的芳香环,或复杂的6元素或5元素环.)

专利信息

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-9603928-B2
优先权日:2013-06-19
标题:Medicinal composition for promoting synthesis of protoporphyrin IX
发明人：ISHIZUKA MASAHIRO; OTO URARA; KAMIYA ATSUKO; TAKAHASHI KIWAMU; TANAKA TOHRU; OZAWA TOSHIYUKI; MORIMOTO KUNIYUKI; WATANABE KEITARO
权利人:SBI PHARMACEUTICALS CO LTD; UNIV OSAKA CITY
摘要:The object of the present invention is to elucidate the resistance mechanism in infections that show resistance to ALA-PDT that uses a single ALA, and to provide a novel treatment method against these infections. The present invention provides a pharmaceutical composition for promoting protoporphyrin IX production in ALA-PDT for treating infection, characterized in that it comprises a substance that promotes the conversion from coproporphyrinogen III to protoporphyrin IX.

专利号:US-7482425-B2
优先权日:1999-08-26
标题:Compositions for lipid matrix-assisted chemical ligation
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-2003018169-A1
优先权日:1999-08-26
标 题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides

专利号:US-11744248-B2
优先权日:2017-08-20
标 题:Disinfectant composition for control of clostridium difficile spore
发明人：SMYTH BRUCE; BRALKOWSKI MICHAEL
权利人:SMYTH BRUCE; BRALKOWSKI MICHAEL; ENVIRO SPECIALTY CHEMICALS INC
摘要:A composition and method for inducing and inflicting damage to cell membranes of microorganism by inducing changes in membrane permeability caused by polycation-induced membrane pores. The control of Clostridium difficile spores with an efficacy of 99.99% on hard surfaces is provided. The invention includes the application of an evaporation-induced self-assembly, surfactant-mediated synthesis or self-condensing polymer, which forms a film which is both flexible on the surface as a nano-polymeric coating and with refractive index yielding a transparent coating. The polymeric matrix includes various biocidal polymeric cationic quaternary salts, one being a silyl quaternary having a kinetic zeta potential to disrupt bacterial spores functions. The polymeric matrix consist of multiple small molecule biocides as well as polymerics biocide combinations not otherwise seen to develop an surface topography of peaks and troughs in the nano range to resist bacterial adhesion factors and subsequent biofilm formation. The surfactants induce self-assembly film topography.

专利号:EP-3011972-A1
优先权日:2013-06-19
标题:Medicinal composition for promoting synthesis of protoporphyrin ix