专利号:US-10604599-B2 优先权日:2018-05-29 标题:Method for green synthesis of uniform- and large-particle-size polystyrene particles 发明人:SHUANG CHENDONG; ZHOU WEIWEI; WANG YUNSHU; LI AIMIN; LI QIMENG; LIU LILI; WANG WEI; ZHANG YI 权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING UNIV & YANCHENG ACADEMY OF ENVIRONMENTAL PROTECTION TECHNOLOGY AND ENGINEERING 摘要:A method for green synthesis of uniform- and large-particle-size polystyrene particles, comprising steps of: prepolymerizing styrene at 70â–¡ to 75â–¡ for 1 h to 6 h in advance while stirring, adding divinylbenzene dissolved with initiators to the styrene, and stirring for 10 min to 30 min to obtain oil phase; heating lactic acid or an aqueous solution of lactic acid to 70â–¡ to 80â–¡, adding the oil phase to dispersed phase by a constant-pressure device, maintaining the temperature for 2 h, heating to 80±5â–¡ and then maintaining the temperature for 1 h, and heating to 85±5â–¡ and then maintaining the temperature for 3 h to 6 h, to obtain polystyrene particles with a uniform particle size ranging from 0.7 mm to 2.0 mm.
专利号:US-2008086013-A1 优先权日:2006-06-15 标 题:Carbometallation of alkynes and improved synthesis of uniquinones 发明人:LIPSHUTZ BRUCE H 权利人:UNIV CALIFORNIA 摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
专利号:US-9126995-B2 优先权日:2011-11-08 标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound 发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU 权利人:NISSAN CHEMICAL IND LTD 摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.
专利号:US-6815214-B2 优先权日:2000-12-29 标 题 :Pharmaceutical uses and synthesis of diketopiperazines 发明人:BOYCE JIM P; HOWBERT J JEFFRY; TABONE JOHN C 权利人:CELLTECH R & D INC 摘要:The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-α, TNF-β and also apoptosis.
专利号:US-8426612-B2 优先权日:2009-04-22 标 题:Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole 发明人:SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO 权利人:SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO; ITALIANA SINT SPA 摘要:The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletriptan or of its salt, comprising the following steps: a) Salifying the intermediate of Formula (6), using a dicarboxylic acid to obtain a derived salt; b) Optionally, purifying said raw salt obtained according to step a) by solvent crystallization to obtain a purified salt of the intermediate of Formula (6); c) Converting said salt of the intermediate of formula (6) according to step a) or said purified salt according to step b) into an intermediate of formula (10); d) Converting the intermediate of Formula (10) into Eletriptan or its salt.
专利号:US-2006128930-A1 优先权日:2004-12-03 标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants 发明人:DHAWAN ASHISH; CHOLLI ASHOK L 权利人:DHAWAN ASHISH; CHOLLI ASHOK L 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
参考标题:One-Pot Synthesis Of Carbamates And Thiocarbamates From Boc-Protected Amines 作者:Hee-Kwon Kim,Anna Lee |发布日期:2016.11 摘要:A Highly Efficient One-Pot Procedure For The Synthesis Of Carbamates And Thiocarbamates Has Been Described. In The Presence Of 2-Chloropyridine And Trifluoromethanesulfonyl Anhydride, The Isocyanate Intermediates Were Generated In Situ For Further Reactions With Alcohols And Thiols To Afford The Desired Carbamates And Thiocarbamates In High Yields.
合成参考文献
参考文献:10.1007/s10482-011-9622-x 摘要:Valle-Rodríguez JO, Hernández-Cortés G, Córdova J, Estarrón-Espinosa M, Díaz-Montaño DM. Fermentation of Agave tequilana juice by Kloeckera africana: influence of amino-acid supplementations. Antonie Van Leeuwenhoek. 2012 Feb;101(2):195–204. doi: 10.1007/s10482-011-9622-x.