CAS: 72482-64-5; 2,4-Difluorobenzoyl Chloride

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CAS号1583-58-0 2,4-二氟苯甲酸 | CAS号79-37-8 草酰氯 | CAS号67640-39-5 Benzoyl fluorid... | CAS号109790-33-2 2,4-difluoro-N-... | CAS号110623-35-3 3H-1,2,4-Triazo... | CAS号185302-85-6 2’,4’-二氟苯基苯甲酰基乙酸甲酯 | CAS号613-94-5 苯甲酰肼 | CAS号1583-58-0 2,4-二氟苯甲酸 | CAS号58101-23-8 3-(2,4-二氟苯基)-3-... | CAS号106614-28-2 2,4-二氟苯甲酸甲酯 | CAS号825649-98-7 (2,4-difluoroph...

2,4-二氟苯甲酸置于氯化亚砜体系中,用96%的收率获得产物2,4-二氟苯甲酰氯
参考文献:合成和评估一系列新的取代的酰基(硫)脲和噻二唑[2,3-A]嘧啶衍生物,它们是流感病毒神经氨酸酶的有效抑制剂.
标题:合成和评估一系列新的取代的酰基(硫)脲和噻二唑[2,3-A]嘧啶衍生物,它们是流感病毒神经氨酸酶的有效抑制剂.
摘要:制备了一系列取代的酰基(硫)脲和2H-1,2,4-噻二唑[2,3-A]嘧啶衍生物,并测试了它们的细胞培养和对流感病毒的酶活性.它们的体外神经氨酸酶抑制活性与培养细胞中的相应活性高度吻合,并且被评价为有效的神经氨酸酶抑制剂.在显示ic(50)s <0.1Microm的类似物中,有16和60被进一步研究,认为它们具有未来发展的最大潜力.描述了代表性化合物的分子对接工作,以提供对其作用机理的更多见解,并进一步使本文中该新系列的观察合理化,该新系列代表了新型的高效和选择性的流感病毒抑制剂.
DOI:10.1016/j.Bmc.2006.08.034

专利信息

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:US-8748459-B2
优先权日:2002-03-29
标 题 :Pyridinoylpiperidines as 5-HT1F agonists
发明人：COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI
权利人:COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI; LILLY CO ELI
摘要:The present invention relates to compounds of formula I: n nor pharmaceutically acceptable acid addition salts thereof, where;n R 1 is C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, substituted C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, substituted C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R 2 is hydrogen, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl-C 1 -C 3 alkyl, or a group of formula II nn n n n n n n n n n n n R 3 is hydrogen or C 1 -C 3 alkyl; n R 4 is hydrogen, halo, or C 1 -C 3 alkyl; n R 5 is hydrogen or C 1 -C 3 alkyl; n R 6 is hydrogen or C 1 -C 6 alkyl; and n n is an integer from 1 to 6 inclusively. n n n n n The compounds of the present invention are useful for activating 5-HT lF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

专利号:WO-2008119015-A2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins

专利号:US-8987452-B2
优先权日:2007-03-27
标 题:Synthesis of thiohydantoins

专利号:US-2010190991-A1
优先权日:2007-03-27
标题 :Synthesis of thiohydantoins

专利号:US-9512103-B2
优先权日:2007-03-27
标题:Synthesis of thiohydantoins