CAS: 68-11-1; Thioglycolic Acid

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CAS号79-14-1 羟基乙酸 | CAS号79-08-3 溴乙酸 | CAS号505-73-7 二硫醇二羟基乙酸 | CAS号79-11-8 氯乙酸 | CAS号7783-06-4 硫化氢 | CAS号7732-18-5 水 | CAS号84495-75-0 methyl (E)-2-((... | CAS号141-84-4 罗丹宁 | CAS号3926-62-3 氯乙酸钠 | CAS号105855-53-6 2,2-diphenyl-1,... | CAS号106873-27-2 2-(3-nitropheny... | CAS号105774-63-8 3-(4-methoxyphe... | CAS号106873-20-5 2-(4-hydroxyphe... | CAS号106145-93-1 2-(3-chlorophen... | CAS号106873-17-0 2-(4-chlorophen... | CAS号105191-14-8 Ethyl 5-cyano-1... | CAS号10574-68-2 3-propan-2-yl-2... | CAS号106263-67-6 1,4,7,10-tetrao... | CAS号55817-29-3 [(氰甲基)硫代]乙酸

二硫醇二羟基乙酸置于盐酸,Tin体系中,化学反应生成 巯基乙酸
参考文献:Ginsburg; Bondzynski,Chemische Berichte,1886,Vol. 19,P. 114,117
标题:Ginsburg; Bondzynski,Chemische Berichte,1886,Vol. 19,P. 114,117

专利信息

专利号:US-7041479-B2
优先权日:2000-09-06
标题 :Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:TRUSTESS OF THE LELAND STANFOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:WO-2012017400-A1
优先权日:2010-08-03
标 题 :Synthesis of acyl-pantetheine derivatives and the use thereof in the synthesis of acyl-coenzyme a derivatives
发明人：VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS
权利人:UNIV NORTHWEST; VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS
摘要:The present invention relates to a novel synthesis method for acyl-pantetheine derivatives. The present invention further relates to the use of said synthesized acyl-pantetheine derivatives as a starting material in the enzymatic synthesis of acyl-coenzyme A derivatives. According to a first aspect thereof, the present invention provides a method for the synthesis of acyl-pantetheine derivatives, the method including the steps of: a) providing a source of pantetheine; b) providing a source of acyl ester; and c) contacting the source of pantetheine with the source of acyl ester to form the corresponding acyl-pantetheine derivative, having the general formula (I), wherein R is an acyl group.The present invention also provides a method for the synthesis of acyl-coenzyme A derivatives as well as the use of a source of pantetheine and a source of acyl ester in the preparation steps of these two methods.

专利号:US-5549974-A
优先权日:1994-06-23
标题:Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. Arrays of thiazolidinones, metathiazanones, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antihistaminic, or antimicrobial activity or use in the treatment of inflammation, hypertension, renal failure, congestive heart failure, uremia and other conditions can be prepared using this method.

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:US-3846399-A
优先权日:1969-04-10
标题:Process for controlled stepwise synthesis of polypeptides
发明人：HIRSCHMANN R; DENKEWALTER R
权利人:MERCK & CO INC
摘要:The invention disclosed herein relates to a novel process for the controlled, stepwise synthesis of polypeptides and proteins. More particularly, it is concerned with a process for the rapid and efficient preparation of polypeptides in which multiple sequential steps are carried out without isolation of intermediate peptides. This process for the controlled stepwise synthesis of polypeptides involves reacting a starting amino acid or peptide (or derivative thereof) with an N-carboxy amino acid anhydride (or derivative thereof) in an aqueous medium under conditions of controlled pH such that the only amino group present in appreciable concentration in reactive form during the course of the reaction is the amino group in the starting amino acid or peptide.

专利号:US-6548276-B2
优先权日:2000-09-06
标题:Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.