CAS: 6635-86-5; 2-Amino-4-Methyl-3-Nitropyridine

相似化合物

53929-59-2 21901-40-6 863878-22-2

上下游产品

CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号33245-30-6 N-(4-甲基吡啶-2-基)硝酰胺 | CAS号123-73-9 2-丁烯醛 | CAS号71090-35-2 2-硝基乙烯-1,1-二胺 | CAS号7664-93-9 硫酸 | CAS号393-53-3 3-氟吡啶-4-羧酸 | CAS号3073-30-1 2-氨基-3,5-二硝基吡啶 | CAS号25782-40-5 2-amino-4-methy... | CAS号3430-27-1 3-氨基-4-甲基吡啶 | CAS号399-88-2 3-氟-4-甲基吡啶 | CAS号21901-18-8 2-羟基-4-甲基-3-硝基吡啶 | CAS号53929-59-2 4-甲基-2,3-二氨基吡啶 | CAS号132272-73-2 ethyl 3-bromo-7... | CAS号100367-40-6 2-氨基-5-溴-3-硝基-4-甲基吡啶 | CAS号343-72-6 3-氟-异烟酸乙酯

2-氨基-4-甲基吡啶置于硫酸,硝酸体系中,化学反应 4.0H,以44%的收率获得产物2-氨基-3-硝基-4-甲基吡啶
参考文献:新型取代的嘌呤等排体:合成,构效关系和细胞毒活性评估
标题:新型取代的嘌呤等排体:合成,构效关系和细胞毒活性评估
摘要:设计和合成了许多吡咯并[2,3-C]吡啶,吡咯并[3,2-D]嘧啶和吡唑并[4,3-D]嘧啶作为抗增殖剂.目标化合物在中央支架上的相似位置具有选定的取代基,可以提取有趣的 Sar.新衍生物对前列腺 (Pc-3) 和结肠 (Hct116) 细胞系的细胞毒活性进行了评估,最有效的类似物显示出从 Nm 到低 µm 范围内的 Ic50 值,而发现它们对正常人成纤维细胞(wi-38).dna 含量的流式细胞术分析显示,最有希望的衍生物 14B置于g2/m 期引起 Pc-3 细胞的统计学显着积累,并诱导 Pc-3 细胞凋亡.
DOI:10.3390/molecules27010247

专利信息

专利号:US-9708317-B2
优先权日:2013-11-25
标 题 :Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
发明人：ZAMBON ALFONSO; NICULESCU-DUVAZ DAN; CHUBB RICHARD; SPRINGER CAROLINE JOY
权利人:CANCER RES TECH LTD; INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); OXY SCIENT LTD; THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
摘要:The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands

专利号:US-2004167329-A1
优先权日:2003-02-21
标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process

专利号:WO-2004076425-A1
优先权日:2003-02-21
标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process

专利号:US-2005113397-A1
优先权日:2002-01-31
标题:Imidazo[1,2-a]pyridine derivative
发明人：TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.