CAS: 65182-56-1; 2-(1,8-Naphthyridin-2-yl)Phenol
该化合物其结构特征为该化合物其结构特征为与酚类相连的环状肾脏.该化合物通常具有与芳香系统相关的特性,包括因氢氧(OH)而具有的稳定性和氢联结潜力.该化合物在室内温度下很固态,在有机溶剂中具有中度溶解性,反映其湿性凝尿激素和苯醇成分.该环的存在表明潜在的生物活动,因为许多含有该结构的化合物因其药用特性和功能特性而已知.此外,该苯性氢氧基组可能有助于其再活性,从而有可能在合成或协调化学中用作离子体.
- 英文名称2-(1,8-Naphthyridin-2-yl)Phenol
- 中文名称2-(1,8-氮杂萘)苯酚
- IUPAC名称2-(1,8-naphthyridin-2-yl)phenol
- 其它别名2-(1,8-Naphthyridin-2-Ly)Phenol; 2-(2-Hydroxyphenyl)-1,8-Naphthyridine; Phenol,2-(1,8-Naphthyridin-2-yl)-; Stat1 Enhancer, 2-Np; 6-(1H-1,8-Naphthyridin-2-Ylidene)-1-Cyclohexa-2,4-Dienone; 2-(1,8-Naphthyridin-2-yl)Phenol 95+%; 8-Naphthyridin-2-yl)Phenol; 6-(1H-1,8-Naphthyridin-2-Ylidene)Cyclohexa-2,4-Dien-1-One
- CAS编号65182-56-1
- MFCD编号:MFCD00203050
- EINECS号:663-431-9
- 分子式:C14H10N2O分子量:222.25
- 产品CID: 1634480
- 产品分类有机原料→分子砌块→芳杂环类化合物→萘啶类化合物
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion - 危险类别急性毒性 类别4(经口)
严重眼损伤 类别1
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Danger(危险)
- 危险描述H302 |吞咽有害.
H318 |造成严重眼损伤.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
- 危险等级8
- UN编号3261.0
- 危险品标志Xn,T
- 包装等级Ⅲ
- 安全声明26-39-45
- 危险类别码22-41-36-25
- WGK Germany3
欧盟法规
ECHA物质C&L通报上下游产品
2-Aminonicotinaldehyde 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione o-hydroxyacetophenone合成工艺路线路线简述
📜1,8-Naphthyridine-N-Monoxide 反应生成 3-氨基-2-氯-6-三氟甲基吡啶
参考文献:Takeuchi Isao; Ozawa Isao; Shigemura Kentaro; Hamada Yoshiki; Ito Tomijos+,Yakugaku Dzassi,Yakugaku Zassni,J. Pharm. Sos. Jar.,1979,99,No 5,45+
标题:Takeuchi Isao; Ozawa Isao; Shigemura Kentaro; Hamada Yoshiki; Ito Tomijos+,Yakugaku Dzassi,Yakugaku Zassni,J. Pharm. Sos. Jar.,1979,99,No 5,45+
海关参考信息
- 2933310010-吡啶
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-4918222-A
优先权日:1984-07-27
标 题 :Process for synthesis of N-acetylglycine
发明人：LIN JIANG-JEN; KNIFTON JOHN F; YEAKEY ERNEST L
权利人:TEXACO INC
摘要:An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
Lynch RA, Etchin J, Battle TE, Frank DA. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61. doi: 10.1158/0008-5472.CAN-06-2439.合成参考文献
参考文献:10.1158/0008-5472.can-06-2439
摘要:Lynch RA, Etchin J, Battle TE, Frank DA. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 01;67(3):1254–61. doi: 10.1158/0008-5472.can-06-2439.
参考文献:10.1186/s12974-024-03171-y
摘要:Wu L, Liu Y, He Q, Ao G, Xu N, He W, Liu X, Huang L, Yu Q, Kanamaru H, Dong S, Zhu S, Yuan Y, Han M, Ling Y, Liu L, Wu C, Zhou Y, Sherchan P, Flores JJ, Tang J, Chen X, He X, Zhang JH. PEDF-34 attenuates neurological deficit and suppresses astrocyte-dependent neuroinflammation by modulating astrocyte polarization via 67LR/JNK/STAT1 signaling pathway after subarachnoid hemorrhage in rats. J Neuroinflammation. 2024 Jul 21;21(1):178.
参考文献:10.1038/s41418-025-01647-9
摘要:Jiang P, Lan C, Zhao S, Zhang X, Lai J, Jing Y, Dai X, Luo L, Li N, Chen Q, Liu Q, Li X, Chen S, Wu Z, Zhou J, Miller H, Wang R, Guan F, Yang L, Kuang W, Du X, Xia P, Huang ZL, He J, Liu Z, Fan Z, Lei J, Liu C. WASH regulates B cell signaling, metabolism and function through STAT1. Cell Death Differ. 2025 Dec 23;(). doi: 10.1038/s41418-025-01647-9.
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