CAS: 64657-18-7; 1,9-Dideoxyforskolin

上下游产品

acetic anhydride 7-deacetyl-1,9-dideoxyforskolin 2,607,12]heptadecan-11-one(2S,7S,13S,6R,9R)-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.02,607,12]heptadecan-11-one 2,7]tetradec-3-yl acetate(1S,7S,9S,3R,5R,8R,14R)-14-acetyloxy-8,9-dihydroxy-1,5,7,11,11-pentamethyl-6-oxa-5-vinyltricyclo[8.4.0.02,7]tetradec-3-yl acetate 1-deoxyforskolin ,12E)-7β-acetoxy-8,14-dihydroxy-15-phenylselanyl-6β-trimethylsilanyloxy-labd-12-en-11-one(14*,12E)-7β-acetoxy-8,14-dihydroxy-15-phenylselanyl-6β-trimethylsilanyloxy-labd-12-en-11-one

📜(2S,7S,13S,6R,9R,14R)-14-Hydroxy-4,4,7,9,13,17,17-Heptamethyl-3,5,8-Trioxa-9-Vinyltetracyclo[11.4.0.02,6.07,12]Heptadecan-11-One置于4-二甲氨基吡啶,高氯酸,偶氮二异丁腈,三正丁基氢锡体系中,用 四氢呋喃,吡啶,氯仿,甲苯 作为反应溶剂,化学反应 133.0H,反应生成 福斯高林1,9-二脱氧
参考文献:伞菌素合成为福司可林和1,9-二脱氧福司可林
标题:伞菌素合成为福司可林和1,9-二脱氧福司可林
摘要:毛喉素(1),一个高度氧化半日花烷二萜类化合物和腺苷酸环化酶的活化剂,已在12个步骤和从ptychantin A(12%总产率合成了4),其已经从地钱中分离ptychanthus纹以非常好的收率.1α-羟基是通过在t-Buoh中用钠将相应的羰基立体选择性还原而得到的.的9α-羟基通过δ的立体选择性环氧化反应引入9.11-Enolether.1,9-Dideoxyforskolin(2)是葡萄糖转运蛋白的抑制剂,已通过8个步骤合成,总产率为37%.通过固态硫代羰基咪唑化并随后进行自由基裂解,可以除去c-1处的羟基.
DOI:10.1021/jo060477E

专利信息

专利号:US-5350864-A
优先权日:1990-05-03
标 题:Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives
发明人：SEAMON KENNETH B; ROBBINS JOAN; LAURENZA ANTONIO
权利人:US HEALTH
摘要:The subject matter of the present invention relates to aminoalkylcarbamates of forskolin and the methods of using these compounds. Specifically, the aminoalkylcarbamates may be utilized in the synthesis of forskolin derivatives. The final derivatives may, in turn, be used in the development of in vivo and in vitro assays designed to study different proteins.

专利号:US-8507219-B2
优先权日:1997-11-25
标 题 :Method of treating inflammation with statins
发明人：SINGH INDERJIT
权利人:SINGH INDERJIT; MUSC FOUND FOR RES DEV
摘要:The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.

专利号:EP-0530252-A1
优先权日:1990-05-03
标 题 :Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives

专利号:WO-9117154-A1
优先权日:1990-05-03
标 题:Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives

专利号:WO-2022235021-A1
优先权日:2021-05-03
标题:Composition for prevention, alleviation, or treatment of dry eye syndrome and dry eye syndrome-related ophthalmologic disease
发明人：JUN IKHYUN; KIM TAE-IM; KIM BO-RAHM
权利人:UNIV YONSEI IACF
摘要:The present invention relates to a composition for prevention, alleviation, or treatment of dry eye syndrome or dry eye syndrome-related ophthalmologic diseases. In the present invention, the protein kinase A (PKA) cell signaling system is activated to effectively reverse the lipid synthesis decrease that may be caused by meibomian gland dysfunction, whereby the lipids secreted from the meibomian gland decrease moisture evaporation from the ocular surface and thus can prevent, alleviate, or treat dry eye syndrome or dry eye syndrome-related ophthalmologic diseases.

专利号:EP-0530252-A4
优先权日:1990-05-03
标题 :Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives