CAS: 645-08-9; 3-Hydroxy-4-Methoxybenzoic Acid

上下游产品

diazomethane methanol diethyl ether 3,4-Diacetoxy-benzoesaeure 3-ethoxy-4-methoxybenzoic acid 3-hydroxy-4-methoxybenzoate ethyl 3-hydroxy-4-methoxybenzoate 2-formyl-5-hydroxy-4-methoxy-benzoic acid

异香兰素置于potassium Hydroxide,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 0.33H,以98%的收率获得产物3-羟基-4-甲氧基苯甲酸
参考文献:Design,Synthesis,And Biological Evaluation Of Chalcone Derivatives As Novel Anticandidal Agents
标题:Design,Synthesis,And Biological Evaluation Of Chalcone Derivatives As Novel Anticandidal Agents
摘要:设计并合成了二十种香豆素衍生物,旨在开发新型抗酵母菌剂.所有化合物均进行了针对白色念珠菌(atcc 10231和十个临床分离株)的抗真菌活性评估.大多数化合物展现出中等的抗酵母菌效力,最低抑菌浓度(mic)值范围为2.0至32.0 μg/ml.其中四种化合物(t4,T6,T19,T20)显示出强大的抗酵母菌活性,Mic值为2.0 μg/ml.化合物t6对白色念珠菌(atcc 10231和四个临床分离株)显示出最强的活性.此外,还尝试将抗酵母菌活性与理化性质进行关联.结果表明,苯环上卤素的引入有利于抗酵母菌活性.
DOI:10.1007/s10600-015-1369-6

专利信息

专利号:US-6372461-B1
优先权日:1998-09-18
标题 :Synthesis of vanillin from a carbon source
发明人：FROST JOHN W
权利人:DIRECTORS OPERATING MICHIGAN S
摘要:A bioengineered synthesis scheme for the production of vanillin from a carbon source is provided. The bioconversion methods of the present invention comprise the steps of microbe-catalyzed conversion of a carbon source to vanillic acid followed by enzyme-catalyzed reduction of the vanillic acid to produce vanillin. As shown in the synthesis scheme of FIG. 2, the microbe-catalyzed conversion step of the present invention requires five enzymes which are provided by a recombinant microbe. In a preferred embodiment, the recombinant microbe is Escherichia coli designed to cause dehydration of 3-dehydroshikimic acid and regioselective methylation of the resulting protocatechuic acid. The enzyme-catalyzed reduction step of the present invention comprises the reduction of vanillic acid to vanillin by aryl-aldehyde dehydrogenase.

专利号:US-6245937-B1
优先权日:1996-11-29
标题 :Liquid phase parallel synthesis of chemical libraries
发明人：CHENG SOAN; SAUNDERS JOHN
权利人:DUPONT PHARMACEUTICALS RES LAB
摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-5476827-A
优先权日:1991-10-24
标题 :Process for the synthesis of aldehydes and their derivatives and catalyst for use thereof
发明人：FERRERO ROSE-MARIE; JACQUOT ROLAND
权利人:RHONE POULENC CHIMIE
摘要:A process for the preparation of aldehydes by hydrogen reduction of carboxylic acids, esters or anhydrides, characterized in that the reduction conducted in the vapor phase, in the presence of a bimetallic catalyst of the ruthenium/tin type.