CAS: 626-72-2; (H-Hocys-Oh)2

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📜L-高半胱氨酸置于air体系中,用 水 作为反应溶剂,化学反应 24.0H,反应生成 L-高胱氨酸
参考文献:谷胱甘肽代谢瘤肽的能量分辨质谱研究作为研究有毒重金属对其代谢过程的干扰的工具.
标题:谷胱甘肽代谢瘤肽的能量分辨质谱研究作为研究有毒重金属对其代谢过程的干扰的工具.
摘要:为了更好地理解金属-生物硫醇缀合物的断裂过程及其生物学意义,已对重金属的谷胱甘肽共轭物,谷胱甘肽代谢瘤的几种硫醇和二硫键进行了能量分辨质谱研究.γ-谷氨酰基化合物的主要裂解过程(无论是硫醇,二硫键,硫醚还是金属-双-硫醇盐形式)都是γ-谷氨酰基残基的损失,Erms数据表明该过程几乎不受硫取代的影响.但是,单-S-谷胱甘肽-汞(II)阳离子损失的γ-谷氨酰基残基是一个高能的过程,可能表明羧基与金属的强配位.而且,含有γ-谷氨酰基残基的离子失去中性汞而反应生成a阳离子的过程比不含有them阳离子的过程要高得多,这表明硫醇/二硫化物系统的氧化还原电位在汞的形式还原中发挥了作用气相中的指示.谷胱甘肽代谢瘤的质子化二硫化物光谱中互补sulf和质子化硫醇片段的出现反映了硫醇/二硫化物氧化还原过程的生物学重要性.碎片的强度比与相应氧化还原对溶液中的还原电位成正比.这一发现可以计算出以前未报告的半胱氨酸甘氨酸
DOI:10.1002/jms.1143

专利信息

专利号:US-5545568-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of compounds on a solid support
发明人：ELLMAN JONATHAN A
权利人:UNIV CALIFORNIA
摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:WO-2024103123-A1
优先权日:2022-11-17
标题 :The synthesis of omapatrilat
发明人：VITALE ROMINA; MARTIN VINCENT ALEXANDRE; FABER WIJNAND; SOMMER ROMAN
权利人:ENDOTHELIUM SCANNING NANOTECHNOLOGY LTD
摘要:Described herein are improved methods of making Compound 1 (4S,7S,10aS)-4-((S)-2- mercapto-3-phenylpropanamido)-5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, or Omapatrilat, and purified Omapatrilat obtained from the improved methods.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-8670941-B2
优先权日:2006-08-18
标题:Methods of determining levels of free amino acids and dipeptides and diagnosing Alzheimer's disease
发明人：FONTEH ALFRED N; HARRINGTON MICHAEL G
权利人:FONTEH ALFRED N; HARRINGTON MICHAEL G; HUNTINGTON MEDICAL RES INST
摘要:Provided herein are methods of diagnosing Alzheimer's disease (“ADâ€?) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markersâ€?) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma. Also provided are methods of simultaneously determining the levels of at least two free amino acids or dipeptides in the biological fluid sample of an individual.