CAS: 596-09-8; 3-Oxo-3H-Spiro[isobenzofuran-1,9'-Xanthene]-3',6'-Diyl Diacetate

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79955-27-4 3348-03-6 7276-28-0

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CAS号108-24-7 乙酸酐 | CAS号2321-07-5 荧光素 | CAS号64-19-7 冰醋酸 | CAS号85-44-9 苯酐 | CAS号620960-03-4 5-bromofluoresc... | CAS号25015-63-8 频那醇硼烷 | CAS号75-36-5 乙酰氯 | CAS号108-46-3 间苯二酚 | CAS号2513-33-9 2',4'-二羟基-2-苯甲酰基苯甲酸 | CAS号2321-07-5 荧光素

📜荧光素置于乙烯酮,丙酮体系中,化学反应生成 荧光素二乙酸盐
参考文献:Alkenyl Derivatives Of Fluorescein
标题:Alkenyl Derivatives Of Fluorescein
摘要:
DOI:10.1021/ja01280A027

专利信息

专利号:US-2024035023-A1
优先权日:2022-06-24
标题 :Computer implemented method for engineering fluorinase enzymes for synthesis of fluorophenyl compounds
发明人：R PRAVIN KUMAR; G GLADSTONE SIGAMANI; L ROOPA; B K NAVEEN; SHETTY ANUJ J; M LIKITH
权利人:KCAT ENZYMATIC PRIVATE LTD
摘要:The present invention discloses a computer-implemented method for engineering fluorinase enzymes towards the synthesis of fluorophenyl compounds. Limited or no mechanistic details of fluorinase enzymes have hindered progress in understanding their catalytic mechanisms for synthesizing synthetic organofluorine compounds. Through a comprehensive computational screening process, specific methionine-sulfonium phenyl substrates, including [(3S)-3-amino-3-carboxypropyl][2,5-difluoro-4-(4-methoxy-2,4-dioxobutyl)phenyl]methylsulfonium, were designed and optimized using quantum chemical optimization techniques. This methodology uncovers crucial information on F— ion attack conformation and the catalytic mechanism of the substrate, leading to the formation of Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate. Furthermore, a protein sequence and 3D modeling-based enzyme screening process was employed to identify the most suitable enzyme for this substrate. The identified enzyme was then engineered using the mechanistic insights gained from the studies, resulting in improved substrate scope, stability and catalytic efficiency. This computer-based approach offers an efficient and precise alternative to traditional trial-and-error methods, advancing the field towards the successful synthesis fluorophenyl compounds.

专利号:WO-2023037158-A1
优先权日:2021-09-09
标题:Process for preparation of crystalline fluorescein sodium from diacetylfluorescein or fluorescein
发明人：AGRAWAL ACHAL NARENDRAKUMAR; CHANDRE TUKARAM NIVRUTTI; TRIPATHI SHUBHAM; AMETA AANCHAL
权利人:MACSEN DRUGS
摘要:The present invention relates to chemical synthesis and purification. Specifically, the present invention relates to a process for preparation of highly pure, moisture free crystalline fluorescein sodium in freeflowing powder form. More particularly, the process relates to synthesis of crystalline fluorescein sodium from diacetyl-fluorescein or fluorescein without using water or aqueous solvents.

专利号:WO-0136626-A9
优先权日:1999-11-15
标 题 :Pentraxin i and pentraxin receptor, inhibitors of said proteins and pharmaceutical compositions containing said compounds
发明人：MESSEGUER PEYPOCH RAMON; ROSELL VIVES ELISABET; MARTINEZ ESCOLA JOSEP MA; RODES GUBERN BLANCA; ADAN PLANA JAUME; PUIG CALVO NURIA; CARCELLER ROSA ANA; MASA ALVAREZ MARC; PIULATS XANCO JAUME; DEN DAAS IZAAK; TRULLAS OLIVA RAMON; DE GREGORIO-ROCASOLANO BARBANY
权利人:MERCK PATENT GMBH; MESSEGUER PEYPOCH RAMON; ROSELL VIVES ELISABET; MARTINEZ ESCOLA JOSEP MA; RODES GUBERN BLANCA; ADAN PLANA JAUME; PUIG CALVO NURIA; CARCELLER ROSA ANA; MASA ALVAREZ MARC; PIULATS XANCO JAUME; DEN DAAS IZAAK; TRULLAS OLIVA RAMON; DE GREGORIO-ROCASOLANO BARBANY
摘要:Described are nucleic acid sequences encoding the human Pentraxin receptor and related proteins and pharmaceutical composition comprising a therapeutically effective amount of (a) Pentraxin I or the human Pentraxin receptor, (b) a nonfunctional variant of the protein of (a), (c) an antibody to the protein of (a) or (b), (d) a nucleic acid sequence encoding the protein of (a) or (b), (e) an antisense RNA sequence, said sequence being capable of inhibiting the synthesis of Pentraxin 1 or the human Pentraxin receptor, or (f) a ribozyme characterized in that it is complementary to a Pentraxin I or human Pentraxin receptor mRNA and can selectively bind to and cleave said mRNA, thus inhibiting the synthesis of Pentraxin I or the human Pentraxin receptor.

专利号:US-2012149888-A1
优先权日:2009-02-22
标 题:Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeuctics, diagnostics, g- tetrad forming oligonucleotides and aptamers
发明人：SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
权利人:SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
摘要:The present invention relates to synthesis, purification and methods to obtain high purity novel 2′-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin-1, bearing ara-2′-omethyl modification have been synthesized. It is anticipated the oligonucleotides incorporating these monomers will exhibit biological activities related to antisense approach approach, design of better SiRNA's, diagnostic agents. Similarly, it is anticipated that oligonucleotides incorporating such novel nucleosides will be useful to develop therapeutic candidates designing stable G-quadruplexes and Aptamers for oligonucleotide structure, folding topology, evaluation of biochemical properties and design and develop as therapeutic agents. It is further anticipated that the nucleosides, phosphates and triphosphates of this invention could develop as therapeutic agents.

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-9657305-B2
优先权日:2006-02-09
标题 :Synthesis of sialic acid in plants
发明人：PACCALET THOMAS; BARDOR MURIEL; RIHOUEY CHRISTOPHE; GOMORD VÉRONIQUE; FAYE LOÃ?C; LEROUGE PATRICE; AQUIN STÉPHANIE; VEZINA LOUIS-PHILIPPE; D'AOUST MARC-ANDRé
权利人:MEDICAGO INC; CENTRE NAT RECH SCIENT; UNIV ROUEN; MEDICAGO INC
摘要:A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.