CAS: 59293-67-3; (2,4-Dichlorophenyl)Methanethiol

上下游产品

dimethyl-dithi°Carbamic acid-(2,4-dichloro-benzyl ester) 2,4-dichloro-1-{[(2,4-dichlorobenzyl)disulfanyl]methyl}benzene 2,4-Dichlorobenzyl chloride thiourea ethyl 2-(2, 4-dichlorophenyl)acetate 5'-O-Dimethoxytritylthymidine-3'-O-[β-cyanoethyl-(S-2,4-dichlorobenzyl)]-phosphorodithioate 5'-O-tritylthymidine-3'-O(S-2,4 dichlorobenzylmethyl)methylphosphonothioate

📜Rrd-251盐酸盐置于sodium Hydroxide体系中,化学反应生成 2,4-二氯苄硫醇
参考文献:Tait; Di Bella; Bondi,Il Farmaco,1990,Vol. 45,# 6,P. 617-630
标题:Tait; Di Bella; Bondi,Il Farmaco,1990,Vol. 45,# 6,P. 617-630

专利信息

专利号:US-7273933-B1
优先权日:1998-02-26
标 题 :Methods for synthesis of oligonucleotides
发明人：KROTZ ACHIM H; RAVIKUMAR VASULINGA T
权利人:ISIS PHARMACEUTICALS INC
摘要:Improved methods for synthesis of oligonucleotides and other phosphorus-linked oligomers are disclosed. The methods include the use of aromatic solvents, alkyl aromatic solvents, halogenated aromatic solvents, halogenated alkyl aromatic solvents, or aromatic ether solvents to achieve deprotection of protected hydroxyl groups.

专利号:US-5714597-A
优先权日:1994-07-07
标题:Use of carbocation scavenger during oligonucleotide synthesis
发明人：RAVIKUMAR VASULINGA; ANDRADE MARK; MULVEY DENNIS; COLE DOUGLAS L
权利人:ISIS PHARMACEUTICALS INC
摘要:During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.

专利号:US-5331096-A
优先权日:1992-04-01
标题 :2- and 3-sulfur derivatives of 1,5-iminosugars
发明人：KOSZYK FRANCIS J; MUELLER RICHARD A
权利人:SEARLE & CO
摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

专利号:US-5342951-A
优先权日:1992-04-01
标题:2- and 3-sulfur derivatives of 1,5-iminosugars
发明人：KOSZYK FRANCIS J; MUELLER RICHARD A
权利人:SEARLE & CO
摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

专利号:US-5268482-A
优先权日:1992-04-01
标 题:2- and 3-sulfur derivatives of 1,5-iminosugars
发明人：KOSZYK FRANCIS J; MUELLER RICHARD A
权利人:SEARLE & CO
摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

专利号:US-5210264-A
优先权日:1992-01-10
标 题 :S-(2,4-dichlorobenzyl)-β-cyanoethyl phosphorothioate diester
发明人：YAU ERIC K
权利人:ISIS PHARMACEUTICALS INC
摘要:The compound S-(2,4-dichlorobenzyl)-β-cyanoethyl phosphorothioate diester is disclosed as useful in the synthesis of phosphorothioate oligonucleotides. In certain embodiments of the invention, this reagent is used to prepare 3'-S-(alkaryl) phosphorothioates. The β-cyanoethyl blocking group can be removed and the resulting diester reacted with a nucleotide having a free 5'-hydroxyl group to yield compounds of the structure: ##STR1## where X is H, a first blocking group, a nucleoside, a nucleotide or an oligonucleotide; Y is H, a second blocking group, a nucleotide or an oligonucleotide; R is an alkaryl or aryl group; n is an integer greater than 0; and Bx is a heterocyclic base. Deblocking of the S-alkaryl or S-aryl moiety yields a phosphorothioate oligonucleotide.