CAS: 56741-33-4; 5-Amino-2-Fluorobenzoic Acid

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CAS号7304-32-7 2-氟-5-硝基苯甲酸 | CAS号445-29-4 邻氟苯甲酸 | CAS号220705-28-2 3-(1,3-benzoxaz... | CAS号84832-00-8 5-氨基-2-氟苄醇 | CAS号56741-34-5 2-氟-5-氨基苯甲酸甲酯

邻氟苯甲酸置于palladium On Activated Charcoal 硫酸,硝酸,环己烯体系中,用 乙醇 作为反应溶剂,化学反应 6.75H,反应生成 5-氨基-2-氟苯甲酸
参考文献:7-苯并恶唑-2-基和7-苯并噻唑-2-基-6-氟喹诺酮类化合物的合成
标题:7-苯并恶唑-2-基和7-苯并噻唑-2-基-6-氟喹诺酮类化合物的合成
摘要:氟喹诺酮类,7-苯并恶唑-2-基-1-乙基-6-氟-1,4-二氢-4-氧喹啉-3-羧酸和7-苯并噻唑-2-基-1-乙基-6-氟-合成了1,4-二氢-4-氧代喹啉-3-羧酸.这些化合物是通过使用gould-Jacobs途径制得的喹啉环系统获得的.通过5-氨基-2-氟苯甲酸与2-氨基苯酚或2-氨基硫代苯酚的环化脱水反应,可得到所需的苯胺,3-苯并恶唑-2-基-4-氟苯胺和3-苯并噻唑-2-基-4-氟苯胺.分别使用多磷酸.
DOI:10.1002/jhet.5570350610

专利信息

专利号:US-9782406-B2
优先权日:2011-10-25
标 题 :Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRADUATE SCHOOL; BEIJING RECIPROCAPHARMACEUTICALS CO LTD; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

专利号:US-9150522-B2
优先权日:2011-10-25
标 题:Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRAD SCHO; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

专利号:JP-H07300461-A
优先权日:1986-01-22
标题 :Intermediate for synthesis of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H, 5H-benzo [i, j] quinolizine-2-carboxylic acid and process for producing the same

专利号:JP-H0759579-B2
优先权日:1986-01-22
标题:Synthesis of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H, 5H-benzo [i, j] quinolizine-2-carboxylic acid

专利号:JP-S62201888-A
优先权日:1986-01-22
标题:Synthesis of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolidine-2-carboxylic acid