CAS: 5428-54-6; 2-Methyl-5-Nitrophenol

上下游产品

CAS号99-55-8 2-氨基-4-硝基甲苯 | CAS号21565-00-4 2-methyl-5-nitr... | CAS号95-53-4 邻甲苯胺 | CAS号120-66-1 乙酰邻甲苯胺 | CAS号7664-93-9 硫酸 | CAS号617-09-4 碳酸二邻甲苯酯 | CAS号7697-37-2 硝酸 | CAS号7647-01-0 盐酸 | CAS号861519-76-8 N-(2-methyl-5-n... | CAS号64-19-7 冰醋酸 | CAS号39183-20-5 2-甲基-5-硝基-6-氯苯酚 | CAS号185684-92-8 7-甲基-4-氨基苯并呋喃 | CAS号2486-79-5 4-Amino-3-methy... | CAS号24224-30-4 3-甲基-9H-咔唑-2-醇 | CAS号2835-95-2 5-氨基邻甲酚 | CAS号619-19-2 4-硝基水杨酸 | CAS号13120-77-9 5-硝基-2-甲基苯甲醚 | CAS号136507-15-8 2-甲氧基-4-硝基苯甲醛 | CAS号138822-91-0 2,2,7-trimethyl... | CAS号124317-01-7 1-methyl-4-nitr...

2-氨基-4-硝基甲苯置于硫酸,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 0.33H,以93%的收率获得产物5-硝基-2-甲基苯酚
参考文献:霉酚酸的非酚吲哚类似物的合成,分子建模和评估.
标题:霉酚酸的非酚吲哚类似物的合成,分子建模和评估.
摘要:基于吲哚-3-甲酰胺衍生物(霉酚酸(mpa)的非酚类似物)的有前途的活性,我们在此报告了一种化合物的合成,该化合物含有两个重要的mpa活性特征:环甲氧基和甲基.合成使用两种策略完成:一种方法,该方法依赖于己烯酸酯侧链的逐步构建,然后是吲哚羧酰胺环系统,并且依赖于1,3-σ重排的收敛路径是关键步骤.对中国仓鼠和人类ii型肌苷单磷酸脱氢酶(impdh)的对接实验表明,该化合物与nad位点具有潜在的结合相互作用.该类似物对mcf7-S,Mcf7-R或igr-Ov1癌细胞没有活性.
DOI:10.1016/j.Bmc.2004.03.048

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-2008242662-A1
优先权日:2005-05-31
标题 :Organic Compounds
发明人：NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI
权利人:NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI
摘要:The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula I, n n n n n n n n n n wherein R1, R2, R11, C, E and D are as defined in the specification.

专利号:US-6090805-A
优先权日:1997-06-18
标 题 :Tocolytic oxytocin receptor antagonists
发明人：WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; PERLOW DEBRA S; STAUFFER KENNETH; FREIDINGER ROGER M
权利人:MERCK & CO INC
摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

专利号:RU-2198879-C2
优先权日:1996-09-25
标题:Derivatives of quinazoline, methods of their synthesis, pharmaceutical compositions comprising thereof, method of attainment of antiangiogenic effect and/or effect of blood vessel permeability reduction in warm-blooded animal

专利号:US-5968938-A
优先权日:1997-06-18
标 题 :Piperazine oxytocin receptor antagonists
发明人：WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; GUARE JR JAMES P; FREIDINGER ROGER M
权利人:MERCK & CO INC
摘要:This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

专利号:RU-2194701-C2
优先权日:1995-12-18
标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using