CAS: 51047-56-4; 3-Piperazin-1-Yl-Pyridazine

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CAS号362661-27-6 3-(4-苄基哌嗪-1-基)-6-氯哌嗪 | CAS号56392-83-7 1-(6-氯哒嗪-3-基)哌嗪

📜1-(6-氯哒嗪-3-基)哌嗪置于palladium On Activated Charcoal 氢气体系中,用 甲醇 作为反应溶剂,化学反应 3.0H,反应生成 1-(6-哒嗪基)哌嗪
参考文献:Synthesis And Evaluation Of Pyridazinylpiperazines As Vanilloid Receptor 1 Antagonists
标题:Synthesis And Evaluation Of Pyridazinylpiperazines As Vanilloid Receptor 1 Antagonists
摘要:A Structurally Biased Chemical Library Of Pyridazinylpiperazine Analogs Was Prepared In An Effort To Improve The Pharmaceutical And Pharmacological Profile Of The Lead Compound N-(4-Tertiarybutylphenyl)-4-(3-Chloropyridin-2-yl)Tetrahydropyrazine-1(2H)-Carboxamide (Bctc). The Library Was Evaluated For Vr1 Antagonist Activity In Capsaicin-Induced (Cap) And Ph 5.5-Induced (Ph) Flipr Assays In A Human Vr1-Expressing Hek293 Cell Line. The Most Potent Vr1 Antagonists Were Found To Have Ic50 Values In The Range Of 9-200Nm With Improved Pharmaceutical And Pharmacological Profiles Versus The Lead Bctc. These Compounds Represent Possible Second-Generation Bctc Analogs. (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2004.09.010