CAS: 50919-06-7; 2-(2-Fluorophenyl)Ethanol

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CAS号451-82-1 邻氟苯乙酸 | CAS号766-49-4 1-乙炔-2-氟苯 | CAS号394-46-7 2-氟苯乙烯 | CAS号57486-67-6 2-氟苯乙酸甲酯 | CAS号584-74-7 邻氟苯乙酸乙酯 | CAS号52721-69-4 2-氟苯乙胺 | CAS号91319-54-9 2-氟苯乙基溴 | CAS号267643-66-3 2-(2-fluorophen... | CAS号694-87-1 苯并环丁烯(BCB) | CAS号130680-89-6 2-(2-fluorophen... | CAS号32607-85-5 [2-(2-氟-苯基)-乙基]-肼 | CAS号1643-26-1 3-(2-氟苯基)丙酸 | CAS号75321-85-6 2-氟苯乙醛 | CAS号877149-83-2 2-氟苯丙腈

1-乙炔基-2-氟苯置于甲酸,F6P(1-)*c16H22N3Ru(1+),水体系中,用 N-甲基吡咯烷酮 作为反应溶剂,化学反应生成 2-氟苯乙醇
参考文献:用于末端炔烃的环境温度反马尔可夫尼科夫还原水合的高活性和空气稳定的钌配合物
标题:用于末端炔烃的环境温度反马尔可夫尼科夫还原水合的高活性和空气稳定的钌配合物
摘要:通过直接添加基于杂原子的亲核试剂将末端炔烃转化为功能化产物是催化的一个重要目标.我们报告了半夹心钌配合物 12 的设计,合成和机理研究,它是炔烃的反马尔科夫尼科夫还原水合的高活性催化剂.12 的关键设计元素涉及一个三齿氮基配体,其中包含一个半稳定的 3-(二甲氨基)丙基取代基.在中性条件下,二甲氨基取代基与钌中心协调,反应生成空气稳定的 18 电子 K(3) 复合物.机理研究表明,二甲氨基取代基在反应介质中从钌中心部分解离(通过质子化),从而产生用于催化的空配位点.这些研究还表明,该取代基通过促进还原剂的活化来提高氢化活性.至少三个催化循环,包括甲酸的脱羧,炔烃的水合和中间体醛的氢化,在由 12 介导的反应中同时运行. 使用少至 2在环境温度下 Mol % 为 12,并且配合物 12 在空气中稳定至少两周.本文概述的研究将 12 确立为迄今为止发现的用于反马尔科夫尼科夫还原水合的最活跃和最实用的催化剂,定义了
DOI:10.1021/ja501738A

专利信息

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6717016-B2
优先权日:2002-01-31
标题:Phosphine compound, transition metal complex containing the same phosphine compound as ligand and asymmetric synthesis catalyst containing the complex
发明人：SHIMIZU HIDEO; SAITO TAKAO
权利人:TAKASAGO PERFUMERY CO LTD
摘要:A phosphine compound of formula (1) n and a phosphine compound of formula (2) n a transition metal complex having the phosphine compound as a ligand and a catalyst for asymmetric hydrogenation including the transition metal complex.