CAS: 4421-09-4; 3,4-(Methylenedioxy)Benzonitrile

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CAS号2089-36-3 胡椒醛肟 | CAS号120-57-0 胡椒醛 | CAS号2620-50-0 3,4-亚甲二氧基苄胺 | CAS号495-76-1 胡椒醇 | CAS号124-63-0 甲基磺酰氯 | CAS号6951-08-2 ethyl benzo[1,3... | CAS号2635-13-4 1-溴-3,4-(亚甲基二氧基)苯 | CAS号773837-37-9 sodium cyanide | CAS号5876-51-7 1-碘-3,4-亚甲基二氧苯 | CAS号1038388-99-6 1-(1,3-benzodio... | CAS号4720-72-3 N-羟基苯并[d][1,3]二... | CAS号40288-65-1 1-(1,3-苯并氧)2-溴乙酮 | CAS号94-53-1 胡椒酸 | CAS号849925-04-8 5-[5-(哌啶-4-基)-1... | CAS号3162-29-6 3',4'-(亚甲基二氧)苯乙酮 | CAS号28281-49-4 3,4-(亚甲基二氧)苯丙酮 | CAS号862574-89-8 1-(1,3-苯并二氧杂环戊烯... | CAS号6120-26-9 6-溴-1,3-苯并二氧戊环-5-甲腈 | CAS号14268-66-7 3,4-亚甲二氧基苯胺

Piperonal-Chlorimin置于氢氧化钾体系中,化学反应生成 胡椒腈
参考文献:Researches On Chlorimines. Iii. The Decomposition Of Certain Aromatic Ald-Chlorimines To Form Nitriles. A Method For The Preparation Of Nitriles From Aldehydes1
标题:Researches On Chlorimines. Iii. The Decomposition Of Certain Aromatic Ald-Chlorimines To Form Nitriles. A Method For The Preparation Of Nitriles From Aldehydes1
摘要:
DOI:10.1021/ja01374A051

专利信息

专利号:WO-2023019298-A1
优先权日:2021-08-20
标 题:Improved method of synthesis of 1-(3',4'-methylene dioxyphenyl)-2-(methylamino) propane (mdma)
发明人：O'MALLEY WILLIAM IAN; WYNNE PAUL MICHAEL
权利人:MIND MEDICINE AUSTRALIA LTD
摘要:The present invention relates to an improved method of synthesis of 1-(3',4'-methylenedioxyphenyl)-2-(methylamino)propane (MDMA) that is of sufficient purity that it can be used for pharmaceutical applications. In particular the present invention provides a method of synthesising MDMA comprising the steps of (a) condensation of piperonal and nitroethane in the presence of a catalysing base to form 1-(3',4'-methylenedioxyphenyl)-2-nitroprop-1-ene (MDP-2-nitropropene), (b) oxidative hydrolysis of MDP-2-nitropropene to form 1-(3',4'methylenedioxyphenyl)-propan-2-one (MDP2P), and (c) reductive amination of MDP2P to 1-(3',4'-methylenedioxyphenyl)-2-(methylamino)propane (MDMA).

专利号:US-8563590-B2
优先权日:2008-03-05
标 题 :Compounds, compositions and methods for the treatment of islet amyloid polypeptide (IAPP) accumulation in diabetes
发明人：LAKE THOMAS; SNOW ALAN D
权利人:LAKE THOMAS; SNOW ALAN D; PROTEOTECH INC
摘要:Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of IAPP or amylin fibril diseases, and the manufacture of medicaments for such treatment.

专利号:US-2015038591-A1
优先权日:2002-05-31
标 题:Compounds, compositions and methods for the treatment of tauopathies
发明人：SNOW ALAN D; CAM JUDY A; CASTILLO GERARDO; HU QUBAI; LAKE THOMAS
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of tauopathies, such as Alzheimer's disease and Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-7919530-B2
优先权日:2002-05-31
标 题 :Compounds, compositions, and methods for the treatment of synucleinopathies
发明人：ESPOSITO LUKE A; CUMMINGS JOEL; HUDSON F MICHAEL; SNOW ALAN D
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-8829198-B2
优先权日:2007-10-31
标 题:Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
发明人：ESPOSITO LUKE A; HUDSON F MICHAEL; LAKE THOMAS; CUMMINGS JOEL; WEIGELE MANFRED; SNOW ALAN D; LARSEN LESLEY
权利人:ESPOSITO LUKE A; HUDSON F MICHAEL; LAKE THOMAS; CUMMINGS JOEL; WEIGELE MANFRED; SNOW ALAN D; LARSEN LESLEY; PROTEOTECH INC
摘要:Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-8916598-B2
优先权日:2003-05-30
标题 :Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies
发明人：ESPOSITO LUKE A; HUDSON F MICHAEL; LAKE THOMAS; CUMMINGS JOEL; WEIGELE MANFRED; SNOW ALAN D
权利人:ESPOSITO LUKE A; HUDSON F MICHAEL; LAKE THOMAS; CUMMINGS JOEL; WEIGELE MANFRED; SNOW ALAN D; PROTEOTECH INC
摘要:Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.