6-氯-5-硝基-4(1H)-嘧啶酮置于盐酸,三乙胺,三氯氧磷体系中,化学反应生成 4,6-二氯-5-硝基嘧啶 参考文献:Discovery Of 5-Nitro-6-Thiocyanatopyrimidines As Inhibitors Of Cryptococcus Neoformans And Cryptococcus Gattii 标题:Discovery Of 5-Nitro-6-Thiocyanatopyrimidines As Inhibitors Of Cryptococcus Neoformans And Cryptococcus Gattii 摘要: DOI:10.1021/acsmedchemlett.1C00038
专利号:US-5656634-A 优先权日:1991-03-21 标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) 发明人:CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J 权利人:PFIZER 摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
专利号:US-5596001-A 优先权日:1993-10-25 标题 :4-aryl-3-(heteroarylureido)quinoline derivatves 发明人:HAMANAKA ERNEST S 权利人:PFIZER 摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.
专利号:CN-112851536-A 优先权日:2021-01-04 标题:A kind of method that utilizes pyrimidine condensing agent to click to construct amide bond and its application in synthesis of amide and polypeptide
专利号:CN-111732535-A 优先权日:2020-08-10 标 题 :Photochemical Synthesis of Heteroarylamines
专利号:CN-112851536-B 优先权日:2021-01-04 标 题:A kind of method that utilizes pyrimidine condensing agent to click to construct amide bond and its application in synthesis of amide and polypeptide
专利号:WO-2019174101-A1 优先权日:2018-03-16 标题 :Method for preparing tenofovir 发明人:YE FANGGUO; LIN HAIBIN; TIAN SONGCHUAN 权利人:ANHUI TWISUN HI TECH PHARMACEUTICAL CO LTD 摘要:The present invention relates to the field of chemical synthesis, and in particular to a method for preparing tenofovir. The compound provided by the present invention has the structure as shown in formula (XII); and the method for preparing tenofovir based on the compound has the advantages of cheap and readily available raw materials, short process route, mild and reliable conditions, being easily applied to industrial production, etc.