CAS: 3844-53-9; H-Lys-Oet.2Hcl

上下游产品

CAS号64-17-5 乙醇 | CAS号657-27-2 L-赖氨酸盐酸盐 | CAS号56-87-1 L-赖氨酸 | CAS号13184-13-9 H-Lys-Lys-OH Hy... | CAS号13184-14-0 三赖氨酸 | CAS号997-20-6 四聚赖氨酸 | CAS号19431-21-1 五聚赖氨酸 | CAS号554-38-1 (2S)-6-amino-2-... | CAS号21743-34-0 (2S)-6-amino-2-... | CAS号7532-36-7 (2S)-6-amino-2-... | CAS号636-93-1 5-硝基愈创木酚

📜Sodium Ethoxide-Ethanol,Dl-α-氨基-ε-己内酰胺 盐酸盐,L-Lysine Ethyl Ester Dihydrochloride 反应生成 L-赖氨酸乙酯二盐酸盐
参考文献:Method For Producing Lysine Ester
标题:Method For Producing Lysine Ester
摘要:赖氨酸酯是通过加热α-氨基-ε-己内酰胺和醇制成的.可以通过添加少量水和酸或碱催化剂来加速反应.

专利信息

专利号:US-2012282652-A1
优先权日:2011-02-28
标题 :Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties
发明人：GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU
权利人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU; POLITECHNIC INST UNIV NEW YORK
摘要:A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide.

专利号:US-8088884-B2
优先权日:2007-09-27
标 题 :Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
发明人：HARRIS J MILTON; BENTLEY MICHAEL DAVID; YOON KUNSANG; FANG ZHIHAO
权利人:HARRIS J MILTON; BENTLEY MICHAEL DAVID; YOON KUNSANG; FANG ZHIHAO; SERINA THERAPEUTICS INC
摘要:The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.

专利号:US-9687558-B2
优先权日:2005-08-03
标题:Antitumoral bioconjugates of hyaluronic acid or its derivatives obtained by indirect chemical conjugation, and their use in the pharmaceutical field
发明人：RENIER DAVIDE; BETTELLA FABIO
权利人:RENIER DAVIDE; BETTELLA FABIO; FIDIA FARM SPA
摘要:The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.

专利号:EP-0324659-B1
优先权日:1988-01-14
标 题 :Enzymatic process for producing immunomodulating pentapeptides and intermediates for use in the process
发明人：AASMUL-OLSEN STIG; ANDERSEN ANDERS J
权利人:CARLBIOTECH LTD AS
摘要:Synthesis of peptides R1-A-B-C-D-E-R2 wherein A, B, C, D and E represent amino acid residues coupled with peptide bonds and A is a omega -amino-or omega -guanidino substituted basic L- or D-amino acid residue or a desamino derivative thereof, B is a omega -amino- or omega -guanidino substituted basic L-amino acid residue, L-Pro or L-dehydroPro, preferably Asp or Glu, C is an acidic L- or D-amino acid residue, preferably Asp or Glu, D is an unpolar, hydrophobic aliphatic or aromatic aryl- or aralkyl group containing L-amino acid residue, preferably Val, Ile or Leu, E is an unpolar, hydrophobic aliphatic or aromatic aryl- or aralkyl group containing L- or D-amino acid residue or a decarboxy derivative thereof, preferably Tyr, Trp, Phe, His or Val, R1 is H or an alpha -amino substituting group, and R2 is OH or an alpha -carboxy substituting group, by sequential coupling of reactive derivatives of said amino acids and/or by fragment coupling of reactive oligopeptide derivatives on the basis of said amino acids. At least one of these coupling reactions is carried out in a completely or partly aqueous medium at pH 3-12, in the presence of a proteolytic enzyme capable of catalyzing the formation of a peptide which, if desired, is coupled with a reactive amino acid derivative or peptide derivative in the presence of the same or another proteolytic enzyme, further enzymatic or chemical coupling reactions being carried out, if necessary. The process, which is particularly suited for synthesizing the immunomodulating pentapeptides thymopentin and spleninopentin and their analogues, comprises several coupling strategies, the preferred enzymes for use in these strategies i.a. including thermolysin, trypsin, subtilisin, carboxypeptidase Y, elastase and bromelain. The process i.a. uses the intermediates Z1ABOR, Z1ABC(OR min )(OR sec ) and Z1ABC(OR)OH, wherein Z1 has the same meaning as R1, and R is alkyl or benzyl.

专利号:WO-2009043027-A2
优先权日:2007-09-27
标 题:Multi-armed forms of activated polyoxazoline and methods of synthesis thereof

专利号:WO-2019076178-A1
优先权日:2017-10-18
标 题:Medical degradable polyurethane with adjustable degradation time and adjustable elongation at break
发明人：ZHANG WENFANG
权利人:COMSCAFFOLDS NANJING MEDICAL DEVICE CO LTD
摘要:The invention provides a medical degradable polyurethane with adjustable degradation time and adjustable elongation at break, a preparation method and application thereof, and can adjust the proportion of each component in the polyurethane synthesis process and select different chain extenders. Control the performance of PU in a wide range, such as PU degradation time, elongation at break, strength, lubricity and hydrophilicity, etc., can choose different properties of medical degradable polyurethane according to the needs of regenerative medicine and medical devices implanted in the body. .