CAS: 3743-22-4; 2-Dimethylaminophenol

该化合物是一种多用途有机化合物,其成分为酚氢氧化物组和芳香环上的二甲基氨替代物.这种结构具有独特的反应性,使其作为制药合成,染料制造和协调化学的中间体具有价值.二甲基氨基电子施食性组增强了其在嗜血性替代反应中的效用,而芬诺丁基允许进一步功能化.它平衡的在极地溶剂和有机溶剂中的溶解性促进了多种合成应用.该化合物因其在生产抗氧化剂和特殊化学品方面的作用而特别引人注目.由于对空气和水的潜在敏感性,需要妥善处理.建议在惰性条件下储存以稳定性.

结构式图片

上下游产品

CAS号50-00-0 甲醛 | CAS号88-75-5 邻硝基苯酚 | CAS号95-55-6 邻氨基苯酚 | CAS号74-88-4 碘甲烷 | CAS号874-52-2 N,N-dimethylani... | CAS号121-69-7 N,N-二甲基苯胺 | CAS号616-38-6 碳酸二甲酯 | CAS号2836-03-5 N,N-二甲基邻苯二胺 | CAS号51301-44-1 3-methylbenzooxazole | CAS号104177-41-5 1,2-Propanediol... | CAS号60309-68-4 [2-(dimethylami... | CAS号3983-38-8 trimethyl-[2-(m...

合成工艺路线路线简述

  • 合成目标产物 2-Dimethylaminophenol 主要起始原料 N,N-Dimethylaniline
  • (文献来源)合成步骤主要原料 N,N-Dimethylaniline
📜N,N-Dimethylbenzeneamine Oxide;Pentachloro-λ5-Stibane 以 硝基甲烷 用作溶剂,化学反应 0.33H,以71.4%的收率获得2-二甲基氨基-苯酚
参考文献:吡啶n-氧化物-Sbcl 5配合物的合成及其分子内和氧转移反应
标题:吡啶n-氧化物-Sbcl 5配合物的合成及其分子内和氧转移反应
摘要:与吡啶n-氧化物或其同系物和sbcl 5在ccl 4中的等摩尔溶液混合,以高收率沉积为无色晶体的1:1络合物.在热解时,这些配合物经历分子内的氧转移,以选择性地产生相应的2-吡啶酮衍生物.N,N-二甲基苯胺n-氧化物和sbcl 5还得到结晶的1∶1配合物,在热分解时,它以非常好的收率生成邻二甲基氨基苯酚.
Doi:10.1016/s0040-4020(01)97935-9

海关参考信息

专利信息


专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:US-4133828-A
优先权日:1975-08-28
标题:Manufacture of dimethylaminobenzenesulfonates
发明人:SCHEUERMANN HORST; HOCH HELMUT
权利人:BASF AG
摘要:Dimethylaminobenzenesulfonates are manufactured by reacting nitrobenzenesulfonates with formaldehyde and hydrogen in the presence of a hydrogenation catalyst containing a metal of atomic number from 24 to 29 and of phosphoric acid and water at a pH of from 2 to 3.5, at from 50 to 150° C, under a pressure of at least 40 bars, with a residence time of from 1 to 15 minutes. The products are starting materials for the synthesis of dyes, especially of rhodamine dyes, oxazine dyes and reactive dyes, and also of pharmaceuticals and pesticides.

专利号:US-7737114-B2
优先权日:2000-04-07
标 题:Didemnin analogs and fragments and methods of making and using them
发明人:JOULLIE MADELEINE M; LIANG BO
权利人:UNIV PENNSYLVANIA
摘要:The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

专利号:US-7651997-B2
优先权日:2000-04-07
标 题 :Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
发明人:JOULLIE MADELEINE M; LIANG BO; DING XIAOBIN
权利人:UNIV PENNSYLVANIA
摘要:The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.

专利号:EP-3049072-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds

专利号:WO-2015048268-A1
优先权日:2013-09-25
标题 :Synthesis of delta 12-pgj3 and related compounds

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:C. van Hooidonk and L. Ginjaar, Rec. Trav. Chim. Pays-Bas 86, 449 (1967).
参考文献:10.1007/s11356-014-3037-y
摘要:Gan L, Cheng Y, Palanisami T, Chen Z, Megharaj M, Naidu R. Pathways of reductive degradation of crystal violet in wastewater using free-strain Burkholderia vietnamiensis C09V. Environmental Science and Pollution Research. 2014 May 28;21(17):10339–48. doi: 10.1007/s11356-014-3037-y.
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