专利号:US-2016318862-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds 发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
专利号:US-4133828-A 优先权日:1975-08-28 标题:Manufacture of dimethylaminobenzenesulfonates 发明人:SCHEUERMANN HORST; HOCH HELMUT 权利人:BASF AG 摘要:Dimethylaminobenzenesulfonates are manufactured by reacting nitrobenzenesulfonates with formaldehyde and hydrogen in the presence of a hydrogenation catalyst containing a metal of atomic number from 24 to 29 and of phosphoric acid and water at a pH of from 2 to 3.5, at from 50 to 150° C, under a pressure of at least 40 bars, with a residence time of from 1 to 15 minutes. The products are starting materials for the synthesis of dyes, especially of rhodamine dyes, oxazine dyes and reactive dyes, and also of pharmaceuticals and pesticides.
专利号:US-7737114-B2 优先权日:2000-04-07 标 题:Didemnin analogs and fragments and methods of making and using them 发明人:JOULLIE MADELEINE M; LIANG BO 权利人:UNIV PENNSYLVANIA 摘要:The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
专利号:US-7651997-B2 优先权日:2000-04-07 标 题 :Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them 发明人:JOULLIE MADELEINE M; LIANG BO; DING XIAOBIN 权利人:UNIV PENNSYLVANIA 摘要:The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
专利号:EP-3049072-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds
专利号:WO-2015048268-A1 优先权日:2013-09-25 标题 :Synthesis of delta 12-pgj3 and related compounds
摘要:C. van Hooidonk and L. Ginjaar, Rec. Trav. Chim. Pays-Bas 86, 449 (1967). 参考文献:10.1007/s11356-014-3037-y 摘要:Gan L, Cheng Y, Palanisami T, Chen Z, Megharaj M, Naidu R. Pathways of reductive degradation of crystal violet in wastewater using free-strain Burkholderia vietnamiensis C09V. Environmental Science and Pollution Research. 2014 May 28;21(17):10339–48. doi: 10.1007/s11356-014-3037-y.