CAS: 28831-65-4; (2S,3S)-4-((E)-3-((R)-1-Carboxy-2-(3,4-Dihydroxyphenyl)Ethoxy)-3-Oxoprop-1-En-1-yl)-2-(3,4-Dihydroxyphenyl)-7-Hydroxy-2,3-Dihydrobenzofuran-3-Carboxylic Acid

上下游产品

4-{2-[1-Carboxy-2-(3,4-Dimethoxyphenyl)Ethoxycarbonyl]Vinyl}-2-(3,4-Dimethoxyphenyl)-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxylic Acid 868258-16-6
(2S,3S)-2-(3,4-Dimethoxyphenyl)-4-{(E)-3-[(R)-3-(3,4-Dimethoxyphenyl)-1-Methoxy-1-Oxopropan-2-Yloxy]-3-Oxoprop-1-Eny}-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxylic Acid 1283147-51-2
2-(3,4-Dimethoxyphenyl)-4-{2-[2-(3,4-Dimethoxyphenyl)-1-Methoxycarbonylethoxycarbony]Vinyl}-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxylic Acid Methyl Ester 55757-14-7
(2S,3S)-4-[(E)-3-[(2R)-3-(3,4-Dimethoxyphenyl)-1-Methoxy-1-Oxopropan-2-Yl]Oxy-3-Oxoprop-1-Enyl]-2-(2,2-Dimethyl-1,3-Benzodioxol-5-yl)-7-Methoxy-2,3-Dihydro-1-Benzofuran-3-Carboxylic Acid 1400055-66-4
(2E)-3-[trans-2-(3,4-Dimethoxyphenyl)-7-Methoxy-3-(Methoxycarbonyl)-2,3-Dihydrobenzo[b]Furan-4-Yl]Prop-2-Enoic Acid
2-(3,4-Dimethoxyphenyl)-4-Formyl-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxylic Acid Methyl Ester 868258-12-2
(2S,3S)-2-(3,4-Dimethoxyphenyl)-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxylic Acid 1283147-53-4
(2S,3S)-[(R)-1-Oxo-1-(Pyrrolidin-1-yl)Propan-2-Yl] 2-(3,4-Dimethoxyphenyl)-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxylate 1283147-57-8 (2S,3S)-2-(2,2-Dimethyl-1,3-Benzodioxol-5-yl)-7-Methoxy-2,3-Dihydro-1-Benzofuran-3-Carboxylic Acid 1400055-53-9 Methyl (2S,3S)-2-(3,4-Dibromophenyl)-7-Methoxy-2,3-Dihydro-1-Benzofuran-3-Carboxylate 1400055-39-1

📜2,2-Dibromo-1-(3,4-Dimethoxyphenyl)Ethene置于哌啶,1-Trimethylsilylquinolinium Iodide,吡啶,盐酸,4-二甲氨基吡啶,1-Di(2-(5-Methylfuryl)Phosphanyl)Ferrocene,正丁基锂,[rhcl(Coe)2]2,4 A Molecular Sieve,Sodium Methylate,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三甲基氢氧化锡体系中,用 甲醇,正己烷,氯仿,1,2-二氯乙烷,甲苯,苯 用作溶剂,化学反应 129.83H,反应生成紫草酸
参考文献:Total Synthesis Of (+)-Lithospermic Acid By Asymmetric Intramolecular Alkylation Via Catalytic C−h Bond Activation
标题:Total Synthesis Of (+)-Lithospermic Acid By Asymmetric Intramolecular Alkylation Via Catalytic C−h Bond Activation
摘要:The Total Synthesis Of (+)-Lithospermic Acid Is Described. The Efficient Synthesis Features An Asymmetric Alkylation Via C-H Bond Activation To Assemble The Dihydrobenzofuran Core Of The Natural Product. This Was Accomplished Via A Chiral Imine-Directed C-H Bond Functionalization And Represents The First Application Of This C-H Activation Method To Natural Product Synthesis. Furthermore,A Challenging Deprotection Of A Late-Stage Permethylated Lithospermic Acid Was Achieved.
Doi:10.1021/ja052680H

专利信息

专利号:US-2024109832-A1
优先权日:2020-11-11
标题:Rapid construction of tetralin, chromane, and indane motifs via cyclative c-h/c-h coupling: four-step total synthesis of (±)-russujaponol f
发明人：YU JIN-QUAN; ZHUANG ZHE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein is a process for achieving a palladium-catalyzed cyclative C(sp3)-H/C(sp2)-H coupling reaction using a native free carboxylic acid as a directing group, an amino acid ligand, and oxidant. The process is useful for synthesizing a range of biologically important scaffolds, including tetralins, chromanes, and indanes.

专利号:US-8716532-B2
优先权日:2009-03-27
标 题:One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation
发明人：SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA
权利人:SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA; COUNCIL SCIENT IND RES
摘要:The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times.

专利号:US-2012165567-A1
优先权日:2009-03-27
标 题 :One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation

专利号:TW-201006841-A
优先权日:2008-05-13
标 题 :Synthesis of dihydrothieno[3,2-d]pyrimidine diols and similar pyrimidine diols