CAS: 269409-97-4; 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenol

上下游产品

2-Iodophenol 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 2-amino-phenol bis(pinacol)diborane 2-hydroxyphenyl boronic acid 2-(4-methylphenyl)phenol 2HF3O2*C14H16N4O2C2HF3O2*C14H16N4O2 2-(2-{[(3-fluorophenyl)methyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

乙酸苯酯置于降冰片烯,Chlorobis(Cyclooctene)-Iridium(I) Dimer,Di-μ-Chlorobis(Norbornadiene)Dirhodium(I),三(4-甲氧苯基)膦体系中,用 四氢呋喃,正庚烷,二氯甲烷 用作溶剂,化学反应 66.25H,反应生成2-(4,4,5,5-四甲基-1,3,2-二杂氧戊硼烷-2-基)苯酚
参考文献:具有无痕,多功能缩醛导向基团的苯酚催化还原正-C-H 甲硅烷基化和二恶唑啉的合成应用
标题:具有无痕,多功能缩醛导向基团的苯酚催化还原正-C-H 甲硅烷基化和二恶唑啉的合成应用
摘要:一种新的,高选择性的键官能化策略,通过两种过渡金属催化剂的中继和无痕缩醛导向基团的使用实现,已被用于在单个容器中轻松形成 C-Si 键并伴随硅基团的官能化. 具体而言,该方法涉及廉价且容易获得的乙酸苯酯的 Ir 催化氢化硅烷化的中继,利用二取代的甲硅烷基合成子提供甲硅烷基缩醛和 Rh 催化的邻-Ch 甲硅烷基化以提供二恶唑啉.随后对硅的亲核加成去除了缩醛导向基团并直接提供未掩蔽的苯酚产物,从而在单个容器中获得硅上的有用官能团.这种用于苯酚催化邻 Ch 甲硅烷基化的无痕缩醛导向基团策略也成功应用于多取代芳烃的制备.值得注意的是,已经开发了一种新的正式 α-氯乙酰导向基团,它允许空间位阻酚的催化还原 Ch 甲硅烷基化.特别是,这种新方法允许获得其他催化途径难以获得的高度通用且分化非常好的 1,2,3-三取代芳烃.此外,所得二恶唑啉可以作为色谱稳定的卤代硅烷等价物,不仅可以去除缩醛导向基团,还可以
Doi:10.1021/jacs.6B04018

专利信息

专利号:US-2009076268-A1
优先权日:2007-09-14
标 题:Facile assembly of fused benzofuro-heterocycles
发明人：FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
权利人:FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
摘要:This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.