CAS: 2302-80-9; 1-Dichlorophosphorylbutane

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CAS号24475-23-8 O,O-dimethyl bu... | CAS号2404-75-3 1-丁基膦酸二乙酯 | CAS号75-44-5 光气 | CAS号78-46-6 丁基膦酸二丁酯 | CAS号106-97-8 丁烷 | CAS号6460-27-1 BUTYLDICHLOROPH... | CAS号7719-12-2 三氯化磷 | CAS号78-46-6 丁基膦酸二丁酯 | CAS号118792-93-1 2-butyl-1,3,2λ5... | CAS号6588-22-3 BUTYLPHOSPHONOT... | CAS号54176-90-8 1-[butyl(chloro...

📜丁基膦酸二甲酯置于草酰氯体系中,用 乙醚 用作溶剂,化学反应 120.0H,以79%的收率获得正丁基膦酰二氯
参考文献:手性烷基膦酸酯对人胃和胰脂肪酶的抑制作用.1,2-二癸酰基-Sn-甘油单层的动力学研究.
标题:手性烷基膦酸酯对人胃和胰脂肪酶的抑制作用.1,2-二癸酰基-Sn-甘油单层的动力学研究.
摘要:对映体纯的烷基膦酸酯化合物rr'P(o)pnp(r = Cnh2N + 1,R'= Oy,Y = Cn'H2N'+ 1,N = N'或n不等于n'; Pnp =对硝基苯氧基)注意到(ry),模拟了在羧酸酯水解过程中发生的过渡态,并作为人胃脂肪酶(hgl)和人胰脂肪酶(hpl)的潜在抑制剂进行了研究.除酶联免疫吸附测定(elisa)外,还用单分子膜技术测试了每种对映体的抑制特性,以便同时估算残留的酶活性和界面脂肪酶结合.对于两种脂肪酶,在导致一半抑制的抑制剂摩尔分数(α50)与链长,R或y之间都没有明显的相关性.(r11Y16)是hpl的最佳抑制剂,(r10Y11)是hgl的最佳抑制剂.我们观测到高纯度的对映异构体,无论是纯对映体烷基膦酸酯抑制剂还是鳞片混合物.我们还首次表明,该对映体选择性识别可以在脂肪酶的催化步骤或初始界面吸附步骤中发生.这些实验结果用两种对映体抑制剂的共价动力学模型和假
Doi:10.1016/s0009-3084(99)00028-6

专利信息

专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:WO-2015053980-A1
优先权日:2013-10-08
标 题 :Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.