CAS: 20493-41-8; Quinapyramine

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      专利号:WO-9724361-A1
      优先权日:1995-12-29
      标 题 :Nucleotide analogs
      发明人：ARIMILLI MURTY N; BISCHOFBERGER NORBERT W; JONES ROBERT J; LEE WILLIAM A; PRISBE ERNEST J
      权利人:GILEAD SCIENCES INC; ARIMILLI MURTY N; BISCHOFBERGER NORBERT W; JONES ROBERT J; LEE WILLIAM A; PRISBE ERNEST J
      摘要:Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

      专利号:US-7439350-B2
      优先权日:1993-09-17
      标题 :Nucleotide analogs
      发明人：BISCHOFBERGER NORBERT W; JONES ROBERT J; ARIMILLI MURTY N; LIN KUEI-YING; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; LEE WILLIAM A; CUNDY KENNETH C
      权利人:GILEAD SCIENCES INC
      摘要:Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

      专利号:US-5886179-A
      优先权日:1993-09-17
      标 题 :Nucleotide analogs
      发明人：ARIMILLI MURTY N; BISCHOFBERGER NORBERT W; JONES ROBERT J; LEE WILLIAM A; PRISBE ERNEST J
      权利人:GILEAD SCIENCES INC
      摘要:Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

      专利号:US-5656745-A
      优先权日:1993-09-17
      标题:Nucleotide analogs
      发明人：BISCHOFBERGER NORBERT; JONES ROBERT J; ARIMILLI MURTY; LIN KUEI-YING; LOUIE MICHAEL; MCGEE LAWRENCE R; PRISBE ERNEST J
      权利人:GILEAD SCIENCES INC
      摘要:Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

      专利号:EP-0719273-B1
      优先权日:1993-09-17
      标题:Nucleotide analogs
      发明人：BISCHOFBERGER NORBERT W; JONES ROBERT J; ARIMILLI MURTY N; LIN KUEI-YING; LOUIE MICHAEL S; MCGEE LAWWRENCE R; PRISBE ERNEST J; LEE WILLIAM A; CUNDY KENNETH C
      权利人:GILEAD SCIENCES INC
      摘要:Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.

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      合成参考文献


      参考文献:10.1080/00034983.1954.11685613
      摘要:Unsworth K. Observations on Antrycide-Fast Strains ofTrypanosoma CongolenseandT. Vivax. Annals of Tropical Medicine & Parasitology. 1954 Jun;48(2):178–82. doi: 10.1080/00034983.1954.11685613.
      参考文献:10.1016/s0368-1742(60)80037-9
      摘要:LEACH TM, EL KARIB EA. Prophylaxis against repeated artificial challenge with Trypanosoma congolense. A comparative trial of antrycide pro-salt and prothidium bromide. J Comp Pathol. 1960 Oct;70():385–95. doi: 10.1016/s0368-1742(60)80037-9.
      参考文献:10.1016/j.vetpar.2010.01.019
      摘要:Gillingwater K, Kumar A, Ismail MA, Arafa RK, Stephens CE, Boykin DW, Tidwell RR, Brun R. In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. Vet Parasitol. 2010 May 11;169(3-4):264–72. doi: 10.1016/j.vetpar.2010.01.019.
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