CAS: 201940-08-1; Tert-Butyl 5-Bromoisoindoline-2-Carboxylate

该化合物是一种化学化合物,其特点是其独特的结构,包括一个叔丁基酯组和一个溴化异丁醇框架.该化合物一般在有机溶剂(如二氯甲烷和乙乙酸乙酸酯)中表现出中等溶解性,而由于其水分缺氧异丁基组,在水中则不易溶解.溴原子的存在带来了显著的再活动,使它有可能成为各种化学变异,包括核分裂替代和混合反应.异丁醇会有助于其芳香特性,影响其电子特性和再活动.此外,该化合物可能展示生物活动,使其对药用化学和药物开发感兴趣.其合成常常涉及多步有机反应,突出其复杂性和实验室环境需要谨慎处理.

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号127168-84-7 5-溴异二氢吲哚 | CAS号6941-75-9 4-溴邻苯二甲酰亚胺 | CAS号912999-49-6 奥那司匹 | CAS号905273-91-8 N-B°C-异吲哚啉-5-硼酸频哪醇酯 | CAS号368441-44-5 2-tert-butyl 5-...

合成工艺路线路线简述

    📜4-溴邻苯二甲酰亚胺置于4-二甲氨基吡啶,Dimethyl Sulfide Borane体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应 28.0H,反应生成5-溴异吲哚啉-2-羧酸叔丁酯
    参考文献:Thiazole Derivative And Applications Thereof
    标题:Thiazole Derivative And Applications Thereof
    摘要:本发明揭示了一种新的噻唑化合物,特别是由化学式(i)表示的化合物,以及其药物组合物和在制备用于治疗与单纯疱疹病毒相关疾病的药物中的应用.

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    专利信息


    专利号:US-2025129021-A1
    优先权日:2023-09-19
    标 题:Small molecule protein synthesis modulators
    发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
    权利人:INTERDICT BIO INC
    摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

    专利号:US-9708336-B2
    优先权日:2014-01-22
    标题 :Metallo-beta-lactamase inhibitors
    发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

    专利号:US-11312722-B2
    优先权日:2019-05-08
    标 题:Hsp90 inhibitors and uses thereof
    发明人：BROWN LAUREN ELAINE; HUANG DAVID S; COWEN LEAH E; WHITESELL LUKE; MARCYK PAUL
    权利人:UNIV BOSTON; GOVERNING COUNCIL UNIV TORONTO
    摘要:Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.

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    合成参考文献


    参考文献:10.1055/s-0032-1318123
    摘要:Synthesis of AT13387. Synfacts. 2013 Feb 15;9(03):0245. doi: 10.1055/s-0032-1318123.
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