专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:WO-2023030277-A1 优先权日:2021-08-30 标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog 发明人:SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN 权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD 摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.
专利号:US-12351573-B2 优先权日:2019-05-09 标 题:Compounds for use in synthesis of peptidomimetics 发明人:AL-ABED YOUSEF; CHENG KAI FAN 权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.
专利号:US-2023159450-A1 优先权日:2020-05-08 标 题 :Dimers for use in synthesis of peptidomimetics 发明人:AL-ABED YOUSEF; ALTITI AHMAD 权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.
专利号:EP-0443532-B1 优先权日:1990-02-20 标题:Temporary minimal protection synthesis of LH-RH analogs 发明人:NESTOR JOHN J JR; MCCLURE NATALIE L 权利人:SYNTEX INC 摘要:A solid phase synthesis of LH-RH analogs in which the amino acids serine and histidine, if present, are side chain protected during the synthesis with groups labile to selected alpha -amino or deprotecting agents.
专利号:US-11753440-B2 优先权日:2018-06-05 标题 :Methods for the synthesis of arginine-containing peptides 发明人:HEIDL MARC; GEOTTI-BIANCHINI PIERO 权利人:DSM IP ASSETS BV 摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a deprotection step that minimizes the transfer of by-products deriving from cleaved sulfonyl-5 based side chain protecting groups from arginine to amino acids carrying electron rich side chains.
[参考文献]: Alessio Innocenti, Et Al. Carbonic Anhydrase Activators. Activation Of The Membrane-Associated Isoform Xv With Amino Acids And Amines. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3430-3. [参考文献]: Alessio Innocenti, Et Al. Carbonic Anhydrase Activators: Activation Of The Archaeal Beta-Class (Cab) And Gamma-Class (Cam) Carbonic Anhydrases With Amino Acids And Amines. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6194-8. [参考文献]: Anthony Bertucci, Et Al. Carbonic Anhydrase Activators. The First Activation Study Of A Coral Secretory Isoform With Amino Acids And Amines. Bioorg Med Chem. 2010 Mar 15;18(6):2300-2303. [参考文献]: Isao Nishimori, Et Al. Carbonic Anhydrase Activators: The First Activation Study Of The Human Secretory Isoform Vi With Amino Acids And Amines. Bioorg Med Chem. 2007 Aug 1;15(15):5351-7. [参考文献]: Kenneth S Brandenburg, Et Al. Inhibition Of Pseudomonas Aeruginosa Biofilm Formation On Wound Dressings. Wound Repair Regen. 2015 Nov-Dec;23(6):842-54.
合成参考文献
摘要:BARENBOIM GM. [Brief-duration fluorescence of DLtryptophan in frozen solutions]. Biofizika. 1962;7():227–32. 参考文献:10.1016/0031-9422(95)00321-w 摘要:Liu Y, Silverstone AL, Wu YM, Yang SF. Formation of N-malonyl-l-tryptophan in water-stressed tomato leaves. Phytochemistry. 1995 Oct;40(3):691–7. doi: 10.1016/0031-9422(95)00321-w.