专利号:US-2004054162-A1 优先权日:2001-10-30 标 题:Molecular detection systems utilizing reiterative oligonucleotide synthesis 发明人:HANNA MICHELLE M 摘要:The present invention provides methods for detecting the presence of a target molecule by the use of nucleotide analogs containing moieties that enable detection. Such analogs may be incorporated into nucleic acids. In one embodiment, nucleotide analogs are used in a process generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators or chain terminators to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase.
专利号:WO-2007007735-A1 优先权日:2005-07-12 标 题 :Synthesis of organic conductive polymerizable material onto metal oxide surface through light irradiation 发明人:TACHIBANA YASUHIRO 权利人:UNIV OSAKA; KANSAI TECH LICENSING ORG CO; TACHIBANA YASUHIRO 摘要:Disclosed is a composite material having a nanostructure containing metal oxide fine particles and an organic conductive polymerizable material. In this composite material, the metal oxide fine particles are joined with one another and the organic conductive polymerizable material is contained in the spaces between the fine particles. In this connection, the organic conductive polymerizable material is a copolymer which is composed of a polythiophene derivative, a thiophene or a derivative thereof and pyrrole, aniline, fluorene, furan or a derivative thereof. Also disclosed is a method for producing such a composite material. This composite material is useful for display elements such as electronic paper.
专利号:US-8658400-B2 优先权日:2008-12-17 标题:Biocatalysts for manufacturing duloxetine alcohol 发明人:SCHNEIDER NINA; HOEFFKEN HANS WOLFGANG 权利人:SCHNEIDER NINA; HOEFFKEN HANS WOLFGANG; BASF SE 摘要:The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.
专利号:US-8617854-B2 优先权日:2008-09-17 标题 :Method for producing L-phenylephrine using an alcohol dehydrogenase of Aromatoleum aromaticum EBN1 (Azoarcus sp. EBN1) 发明人:BREUER MICHAEL; PLETSCH ANDREAS; HAUER BERNHARD; SIEGEL WOLFGANG 权利人:BREUER MICHAEL; PLETSCH ANDREAS; HAUER BERNHARD; SIEGEL WOLFGANG; BASF SE 摘要:The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.
专利号:EP-1551403-B1 优先权日:2002-10-10 标 题 :5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia 发明人:SEMPLE GRAEME; AVERBUJ CLAUDIA; SKINNER PHILIP; GHARBAOUI TAWFIK; SHIN YOUNG-JUN 权利人:ARENA PHARM INC 摘要:The present invention relates to certain pyrazole carboxylic acid derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, as antilipolytic agents and against for the receptor RUP25, wherein: R2 is H, halogen, C1-12 alkyl or C1-12 haloalkyl; and R3 is C3-6 cycloalkyl, C1-12 alkyl, C1-12 haloalkyl, C3-6 cycloalkyl-C1-4-alkylene, aryl-C1-4-alkylene or heteroaryl-C1-4-alkylene, wherein said aryl-C1-4-alkylene and heteroaryl-C1-4-alkylene can be optionally substituted 1 to 5 substituents selected from the substituents listed in the claims. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for pharmaceutical compositions in combination with other active agents, for example, those agents belonging to the class of alpha-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, thiazolidinedione and the like.
专利号:EP-1622923-A4 优先权日:2003-04-29 标题 :MOLECULAR DETECTION SYSTEMS USING THE REITERATIVE SYNTHESIS OF OLIGONUCLEOTIDES
参考文献:10.1021/jm0606185 摘要:Wu X, Wan Y, Mahalingam AK, A. M. S. Murugaiah,, Plouffe B, Botros M, Karlén A, Hallberg M, Gallo-Payet N, Alterman M. Selective Angiotensin II AT2Receptor Agonists: Arylbenzylimidazole Structure−Activity Relationships. J. Med. Chem. 2006 Nov 09;49(24):7160–8. doi: 10.1021/jm0606185.