CAS: 14176-10-4; 2-(Azepan-1-yl)Ethyl 2-Cyclohexyl-2-Thiophen-3-Ylacetate
- 英文名称2-(Azepan-1-yl)Ethyl 2-Cyclohexyl-2-Thiophen-3-Ylacetate
- 中文名称西替地尔
- IUPAC名称-Thiopheneacetic acid, alpha-cyclohexyl-, 2-(hexahydro-1H-azepin-1-yl)ethyl ester
- 其它别名Cetiedil
- CAS编号14176-10-4
- EINECS号:238-028-2
- FDA UNII编号:621RT200TO
- 分子式:C20H31NO2S分子量:349.538
- 产品CID: 639530
- 同类组份化合物CAS14176-10-4 (free base)16199-90-9 (HCl)
- 产品分类有机原料 → 有机杂环化合物 → 氮杂环庚烷
物理性质
MSDS等安全信息
上下游产品
环己基-3-噻吩基乙酸乙酯 Ethyl 2-Cyclohexyl-2-(3-Thienyl)Ethanoate 51536-25-5合成工艺路线路线简述
📜噻吩-3-乙酸乙酯置于对甲苯磺酸,Lithium Diisopropyl Amide体系中,用 N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 33.75H,反应生成西替地尔
参考文献:外消旋西替地尔的有效新合成和利用温和条件制备 α-酮羧酸的新途径
标题:外消旋西替地尔的有效新合成和利用温和条件制备 α-酮羧酸的新途径
摘要:我们描述了规定的外消旋药物西替地尔 [(+/-)-2-Cyclohexyl-2-(3-Thienyl)Ethanoic Acid 2-(Hexahydro-1 H-Azepin-1-yl)Ethylester] 的新有效合成.此外,我们在此报告了一种高产大规模的酸前体 7 途径,随后能够大规模合成西替地尔的手性形式,并进行详细的药理学研究.此外,我们描述了一种从容易获得或容易获得的醛开始制备 α-酮羧酸的新途径:所使用的温和条件使其适用于具有生物学意义的分子.
Doi:10.1055/s-2007-977414
海关参考信息
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2909110000-乙醚
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专利信息
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
专利号:RU-2197482-C2
优先权日:1997-04-22
标 题 :Substituted phenyl derivatives, method of their synthesis, pharmaceutical composition comprising thereof and method of treatment (variants)
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Abu-Salah KM, Gambo AH. An analysis of the mechanism by which cetiedil inhibits sickling. Life Sci. 2002 Jan 18;70(9):1003-11. doi: 10.1016/s0024-3205(01)01477-1. 198(1):176-86. 77(5):2955-9. doi: 10.1073/pnas.77.5.2955.
4: Orringer EP, Powell JR, Cross RE, Rogers JF, Wojcieszyn O, Phillips JC, Reed J, Ng KT, Berkowitz LR. A single-dose pharmacokinetic study of the antisickling agent cetiedil. Clin Pharmacol Ther. 1986 Mar;39(3):276-81. doi: 10.1038/clpt.1986.39. 48(8):851-7. doi: 10.1111/j.2042-7158.1996.tb03986.x. 17(3):217-23. doi: 10.1002/ajh.2830170302. 44(20):3244-53. doi: 10.1021/jm001113w. 62(1):113-8. doi: 10.1046/j.1471-4159.1994.62010113.x. 16(9):402-7. 69(3):589-94. doi: 10.1172/jci110485.
合成参考文献
参考文献:10.1093/oxfordjournals.jbchem.a135289
摘要:Chiba T, Asakura T, Kakinuma K. Effect of cetiedil on the superoxide-generating system of porcine neutrophils. J Biochem. 1985 Aug;98(2):355–61. doi: 10.1093/oxfordjournals.jbchem.a135289.
参考文献:10.1002/jps.2600750707
摘要:Narasimhan C, Fung LW-. Molecular Properties of Cetiedil and its Interactions with Erythrocyte Membranes. Journal of Pharmaceutical Sciences. 1986 Jul;75(7):654–9. doi: 10.1002/jps.2600750707.
参考文献:10.1007/978-1-4615-5891-0_36
摘要:Fitzgerald RS, Shirahata M, Ishizawa Y. The presynaptic component of a cholinergic mechanism in the carotid body chemotransduction of hypoxia in the cat. Adv Exp Med Biol. 1996;410():245–52. doi: 10.1007/978-1-4615-5891-0_36.
参考文献:10.1016/j.ejphar.2003.10.013
摘要:Narenjkar J, Marsh SJ, Assem el-SK. Inhibition of the antigen-induced activation of RBL-2H3 cells by charybdotoxin and cetiedil. Eur J Pharmacol. 2004 Jan 12;483(2-3):95–106. doi: 10.1016/j.ejphar.2003.10.013.
参考文献:10.1016/j.ejphar.2003.10.014
摘要:Narenjkar J, Assem el-SK, Ganellin CR. Inhibition of the antigen-induced activation of RBL-2H3 cells by cetiedil and some of its analogues. Eur J Pharmacol. 2004 Jan 12;483(2-3):107–16. doi: 10.1016/j.ejphar.2003.10.014.
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