CAS: 141-23-1; Methyl 12-Hydroxyoctadecanoate

该化合物是一种脂肪酸酯,产自12-氢氧盐酸,其特征是碳位第12处的氢氧基功能组,该化合物具有极好的润滑性,热稳定性,与各种聚合物和涂料相容,因此在塑料,润滑剂添加剂和地表变异剂等工业应用中具有价值,它的极性氢氧基组会增强粘合和散射特性,而其酯结构则会降低挥发性和对氧化的抗药性. 甲基12-Hydroxyearate还被用于化妆品和个人护理配方,以产生发热和增厚效应. 它平衡的缺水性和再活性使它成为特殊化学合成的多功能中间体.

结构式图片

相似化合物

106-14-9 51883-36-4 76062-97-0

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

methyl ricinoleate methyl 12-oxo°Ctadecanoate methyl ricinoleate n-heptan1ol12-Hydroxystearic acid undecanedioic acid methyl vaccenate Methyl (R,S)-12-fluorostearate

合成工艺路线路线简述

    📜12-羟基硬脂酸置于碘体系中,化学反应 35.0H,反应生成12-羟基硬脂酸甲酯
    参考文献:碘催化的温和有效的酯化和酯交换反应方法
    标题:碘催化的温和有效的酯化和酯交换反应方法
    摘要:发现碘是用于羧酸与醇的酯化的实用且有用的路易斯酸催化剂.碘的高催化活性可用于通过不同的醇(包括叔醇和位阻的伯醇和仲醇)进行酯的酯交换反应.提出的方法对于同时酯化和酯交换反应特别有效.
    Doi:10.1016/s0040-4039(01)02235-3

    海关参考信息

    专利信息


    专利号:US-2025049714-A1
    优先权日:2021-12-09
    标题 :Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications
    发明人:ANDERSON DANIEL GRIFFITH; RHYM LUKE HYUNSIK; LI BOWEN; GORDON AKIVA; RAJITH SINGH MANAN; WITTEN JACOB
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).

    专利号:WO-2023107648-A3
    优先权日:2021-12-09
    标题:Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications

    专利号:US-9314021-B2
    优先权日:2004-11-03
    标题 :Formulations containing insect repellent compounds
    发明人:SCIALDONE MARK A
    权利人:DU PONT
    摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints ( Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, and compositions thereof, which also has fragrance properties, may be used commercially for its insect repellent properties.

    专利号:WO-2023107648-A2
    优先权日:2021-12-09
    标 题:Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications

    专利号:RU-2413738-C2
    优先权日:2005-04-29
    标题:Polyesterpolyols having secondary alcohol groups and use thereof in synthesis of polyurethanes, such as flexible foamed polyurethanes

    专利号:JP-H05222200-A
    优先权日:1991-10-10
    标题 :Synthesis of silicone-polyether / alkyl copolymer

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:A General Approach To Intermolecular Olefin Hydroacylation Through Light‐induced Hat Initiation: An Efficient Synthesis Of Long‐chain Aliphatic Ketones And Functionalized Fatty Acids
    作者:Subhasis Paul,Joyram Guin |发布日期:2021.3
    摘要:Hydroacylation Protocol Applies To A Wide Array Of Substrates Bearing Numerous Functional Groups And Many Complex Structural Units. The Reaction Proves To Be Scalable (Up To 5 G). Different Functionalized Fatty Acids, Petrochemicals And Naturally Occurring Alkanes Can Be Synthesized With This Protocol. A Radical Chain Mechanism Is Implicated In The Process.

    合成参考文献


    摘要:Hawley, G.G. The Condensed Chemical Dictionary. 9th ed. New York: Van Nostrand Reinhold Co., 1977., p. 570
    摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知