CAS: 911637-19-9; (S)-1-(2-Amino-4-(2,4-Bis(Trifluoromethyl)-5,8-Dihydropyrido[3,4-D]Pyrimidin-7(6H)-yl)-4-Oxobutyl)-5,5-Difluoropiperidin-2-One

📜(R)-1-(2β-Amino-4-(2,4-Bis(Trifluoromethyl)-5,8-Dihydropyrido[3,4-D]Pyrimidin-7(6H)-yl)-4-Oxobutyl)-5,5-Difluoropiperidin-2-One置于三羟甲基丙烷 三(3-巯基丙酸酯),偶氮二异丁腈体系中,用 对二甲苯 作为反应溶剂,化学反应生成 吉格列汀
参考文献:Us2023/142248
标题:Us2023/142248

专利信息

专利号:US-2012282255-A1
优先权日:2011-04-07
标题 :Methods and compositions for the treatment of alcoholism and alcohol dependence
发明人：PLUCINSKI GREG
权利人:PLUCINSKI GREG
摘要:The present invention provides for compositions and methods for treating or preventing addictive and compulsive diseases and disorders, particular alcohol-related diseases and disorders, disclosed herein. The GLP activators of the present invention are effective against various alcohol and drug dependency diseases. In accordance with the invention, the present compositions and methods can be used to intercede upstream or downstream in the signal transduction cascade involved in GLP action to treat various alcohol and drug dependency diseases. In one embodiment, the synthesis or release of endogenous GLP can be stimulated. In another embodiment, the endogenous synthesis or release of another molecule active in the cascade downstream from GLP, (e.g., a molecule produced in response to GLP binding to a receptor), can be stimulated. Accordingly, the methods and compositions of the invention are useful for preventing, treating, diagnosing, or monitoring the progression various alcohol and drug dependency diseases disclosed herein.

专利号:US-9963685-B2
优先权日:2013-02-28
标题 :Engineered transaminase polypeptides for industrial biocatalysis
发明人：QUINTANAR-AUDELO MARTINA; EBERHARD ELLEN; NAZOR JOVANA; SMITH DEREK; WANG CUIXIA
权利人:CODEXIS INC
摘要:The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

专利号:WO-2025096684-A1
优先权日:2023-10-30
标题 :Err modulators
发明人：ELGENDY BAHAA; HEGAZY LAMEES; BURRIS THOMAS
权利人:UNIV OF HEALTH SCIENCES AND PHARMACY IN ST LOUIS
摘要:In one aspect, the present disclosure describes compounds which may be used to modulate the activity of an estrogen receptor-related orphan receptor (EER). Also described are pharmaceutical formulations, methods of synthesis and uses thereof.

专利号:WO-2025096683-A1
优先权日:2023-10-30
标 题:Err modulators
发明人：ELGENDY BAHAA; HEGAZY LAMEES SHAMSELDIN; BURRIS THOMAS PATRICK
权利人:UNIV OF HEALTH SCIENCES AND PHARMACY IN ST LOUIS
摘要:In one aspect, the present disclosure describes compounds that may be used to modulate the activity of an estrogen receptor-related orphan receptor (EER). Also described are pharmaceutical formulations, methods of synthesis and uses thereof.

专利号:US-2020255394-A1
优先权日:2018-09-26
标题 :Crystalline solid forms of n-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis

专利号:CA-3113037-A1
优先权日:2018-09-26
标 题 :Crystalline forms of n-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oopropan-2-yl)-4-(4-(2-methyl-5-(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl)phenl)butanamide and methods of their synthesis