CAS: 89570-83-2; 2-Hydrazinyl-3-(Trifluoromethyl)Pyridine

该化合物是一种有机化合物,其特点是存在一个氢氨功能组和一个附于一个环的三氟甲基组,该化合物通常具有与氢和相关的特性,例如由于氢和可能具有核素特性,可参与各种化学反应,包括凝聚和替代反应.三氟甲基组可增强化合物的脂性,并可影响其再活性和稳定性.此外,氟原子的存在往往具有独特的电子特性,使得对药用化学和材料科学的兴趣复合.该化合物还可能展示生物活动,可在药物开发或农业化学方面加以探讨.与许多含氮的乙型循环一样,它可能被用于合成更为复杂的分子或作为各种化学过程的中间体.应当观测安全性和处理防范措施,因为与氢氨衍生物具有潜在的毒性.

结构式图片

相似化合物

183610-70-0 129015-67-4 1374652-48-8

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号65753-47-1 2-氯-3-(三氟甲基)吡啶

合成工艺路线路线简述

  • 65753-47-1 = 89570-83-2
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; Rt; Reflux
    标题:Metal Free [4+1] And [5+1] Annulation Reactions To Prepare Heterocycles Using Dmf And Its Derivatives As One-Carbon Source
    作者:Xu,Yiwen; Shen,Bei; Liu,Lingfeng; Qiao,Chunhua
    参考文献:Tetrahedron Letters 日期:2020 卷标:61(19)]

    65753-47-1 = 89570-83-2 [标题:Reaction Conditions
    标题:Preparation Of [(Aminoalkyl)Thio]-1,2,4-Triazolo[4,3-A]Pyridines And -Quinolines As Analgesics
    参考文献:European Patent Organization]

    65753-47-1 = 89570-83-2
    反应条件:1.1 Reagents: Hydrazine
    标题:Preparation Of Triazolopyridines As Herbicides
    参考文献:European Patent Organization]

    175205-82-0 = 89570-83-2
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 29 H,105 °C
    标题:Tetrahydroindazole Inhibitors Of Cdk2/cyclin Complexes
    作者:Lee,Jae Chul; Hong,Kwon Ho; Becker,Andreas; Tash,Joseph S.; Schonbrunn,Ernst; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2021 卷标:214
📜2-溴-3-三氟甲基吡啶置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 29.0H,以53%的收率获得产物2-肼基-3-三氟甲基吡啶
参考文献:Tetrahydroindazole Inhibitors Of Cdk2/cyclin Complexes
标题:Tetrahydroindazole Inhibitors Of Cdk2/cyclin Complexes
摘要:
DOI:10.1016/j.Ejmech.2021.113232

海关参考信息

专利信息


专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CN-114540846-B
优先权日:2022-02-10
标题:Synthesis method of 1,2, 4-triazolo six-membered nitrogen heterocycle-3-amine

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Synthesis Of Diverse Nitrogen-Enriched Heterocyclic Scaffolds Using A Suite Of Tunable One-Pot Multicomponent Reactions
作者:Guillermo Martinez-Ariza,Muhammad Ayaz,Federico Medda,Christopher Hulme |发布日期:2014.6.6
摘要:Anhydrides, And Acyl Chlorides) Five-Membered Triazolopyridine Scaffolds (B, D, F, G) Are Generated In A Single Step. Furthermore, The Use Of Phenyl Hydrazine Enables Access To Dihydroindazole-Carboxamides, Devoid Of A Bridge-Head Nitrogen (C). All Protocols Are Robust And Tolerate A Diverse Collection Of Reactants, And As Such, It Is Expected That The New Scaffolds And Associated Chemistry Will Garner

合成参考文献


摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 92.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知