621-23-8 + 1535-67-7 = 830-79-5 反应条件:1.1 Catalysts: Tin Tetrachloride Solvents: Dichloromethane; 2 H,Rt1.2 Reagents: 1-Hydroxy-1,2-Benziodoxol-3(1H)-One 1-Oxide Solvents: Dimethyl Sulfoxide,Water; 2 H,Rt1.3 Reagents: Sodium Thiosulfate Solvents: Water; Rt1.4 Reagents: Sodium Bicarbonate Solvents: Water; Basified,Rt 标题:Electrophilic Aromatic Formylation With Difluoro(Phenylsulfanyl) Methane 作者:Betterley,Nolan M.; Et Al 参考文献:Synthesis 日期:2018 卷标:50(10) 页码:2033-2040]
621-23-8 + 1535-67-7 = 830-79-5 反应条件:1.1 Catalysts: Bismuth Triflate Solvents: 1,1,1,3,3,3-Hexafluoro-2-Propanol; 5 Min,Rt1.2 Solvents: 1,1,1,3,3,3-Hexafluoro-2-Propanol; 12 H,Rt1.3 Reagents: 2-Iodoxybenzoic Acid Solvents: Dimethyl Sulfoxide,Water; 1 H,Rt1.4 Reagents: Sodium Sulfite Solvents: Water; Rt1.5 Reagents: Sodium Bicarbonate Solvents: Water; Basified,Rt 标题:Bi(Otf)3 Enabled C-F Bond Cleavage In Hfip: Electrophilic Aromatic Formylation With Difluoro(Phenylsulfanyl)Methane 作者:Betterley,Nolan M.; Et Al 参考文献:Asian Journal Of Organic Chemistry 日期:2018 卷标:7(8) 页码:1642-1647]
61040-78-6 = 830-79-5 反应条件:1.1 Reagents: Oxygen,Abts Catalysts: Laccase Solvents: Water 标题:Comparing The Catalytic Efficiency Of Some Mediators Of Laccase 作者:Fabbrini,Maura; Et Al 参考文献:Journal Of Molecular Catalysis B: Enzymatic 日期:2002 卷标:16(5-6) 页码:231-240]
61040-78-6 = 830-79-5 反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium Solvents: Toluene; 90 °C 标题:Highly Dispersed Palladium Nanoparticles Supported On An Imidazolium-Based Ionic Liquid Polymer: An Efficient Catalyst For Oxidation Of Alcohols 作者:Karimi,Z.; Et Al 参考文献:Russian Chemical Bulletin 日期:2022 卷标:71(6) 页码:1194-1203]
621-23-8 + 4885-02-3 = 830-79-5 反应条件:1.1 Reagents: Titanium Tetrachloride Solvents: Dichloromethane; 0 °C; 1 H1.2 45 Min1.3 Reagents: Ammonium Chloride Solvents: Water; 2 H 标题:Formylation Of Electron-Rich Aromatic Rings Mediated By Dichloromethyl Methyl Ether And Ticl4: Scope And Limitations 作者:Ramos-Tomillero,Ivan; Et Al 参考文献:Molecules 日期:2015 卷标:20(4) 页码:5409-5422]
621-23-8 = 830-79-5 反应条件:1.1 Reagents: Boron Trifluoride Etherate,Triethyl Orthoformate Solvents: Dichloromethane1.2 Reagents: Water 标题:First Reactions Of Dialkoxycarbenium Tetrafluoroborates With Pyrroles,5H-Dibenz[b,F]Azepines,And Electron-Rich Arenes 作者:Pindur,U.; Et Al 参考文献:Journal Of Heterocyclic Chemistry 日期:1989 卷标:26(6) 页码:1563-8]
62778-01-2 = 830-79-5 反应条件:1.1 Reagents: Triethylamine Catalysts: Triphenylphosphine Solvents: Dmso-D6; Rt -> 120 °C; 12 H,120 °C 标题:Triphenylphosphine/triethylamine-Mediated Decarboxylation Of α-Oxocarboxylic Acids And Application In A One-Pot Synthesis Of Deuterated Aldehydes. 作者:Niu,Guang-Hao; Et Al 参考文献:Asian Journal Of Organic Chemistry 日期:2016 卷标:5(1) 页码:57-61]
= 830-79-5 反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 6 H,Rt -> Reflux2.1 Reagents: Phosphorus Oxychloride; 15 - 20 Min,0 °C; 1 H,Rt2.2 Reagents: Potassium Hydroxide Solvents: Water; Basified,0 °C 标题:Synthesis Of Structurally Diverse Biflavonoids 作者:Sum,Tze Jing; Et Al 参考文献:Tetrahedron 日期:2018 卷标:74(38) 页码:5089-5101]
= 830-79-5 反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 8 H,60 - 70 °C2.1 Reagents: Phosphorus Oxychloride; 0 °C; 1 H,Rt2.2 Reagents: Potassium Hydroxide Solvents: Water; Basified,Cooled 标题:Synthesis Of New C-Dimethylated Chalcones As Potent Antitubercular Agents 作者:Anandam,Rambabu; Et Al 参考文献:Medicinal Chemistry Research 日期:2018 卷标:27(6) 页码:1690-1704]
63665-97-4 = 830-79-5 反应条件:1.1 -2.1 Reagents: Phosphorus Oxychloride 标题:The Vilsmeier Reaction Of Fully Conjugated Carbocycles And Heterocycles 作者:Jones,Gurnos; Et Al 参考文献:Organic Reactions (Hoboken 日期:1997 卷标:49]
621-23-8 = 830-79-5 + 2510-49-8 反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 0 °C; 2 H,0 °C1.2 0 °C; 2 H,Rt1.3 Solvents: Methanol; 30 Min,Rt1.4 Reagents: Potassium Carbonate,Iodine; 0 °C; 41 H,Rt1.5 Reagents: Sodium Sulfite Solvents: Water; Rt 标题:Facile Preparation Of Aromatic Esters From Aromatic Bromides With Ethyl Formate Or Dmf And Molecular Iodine Via Aryllithium 作者:Ushijima,Sousuke; Et Al 参考文献:Tetrahedron 日期:2012 卷标:68(24) 页码:4701-4709]
621-23-8 = 830-79-5 反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 45 Min,0 °C; 1 H,0 °C1.2 Reagents: Potassium Carbonate Solvents: Water; Ph 9 - 10 标题:Enantioselective Ring Opening Of Meso-Epoxides With Silicon Tetrachloride Catalyzed By Pyridine N-Oxides Fused With The Bicyclo[3.3.1]Nonane Framework 作者:Neniskis,Algirdas; Et Al 参考文献:European Journal Of Organic Chemistry 日期:2015 卷标:2015(28) 页码:6359-6369]
949593-49-1 = 830-79-5 反应条件:1.1 Reagents: Phosphorus Oxychloride; 0 °C; 1 H,Rt1.2 Reagents: Potassium Hydroxide Solvents: Water; Basified,Cooled 标题:Synthesis Of New C-Dimethylated Chalcones As Potent Antitubercular Agents 作者:Anandam,Rambabu; Et Al 参考文献:Medicinal Chemistry Research 日期:2018 卷标:27(6) 页码:1690-1704]
621-23-8 + 93-61-8 = 830-79-5 反应条件:1.1 Reagents: Phosphorus Oxychloride; 5 - 10 Min,40 - 50 °C1.2 15 Min,70 °C1.3 Solvents: Water; 1 H,Cooled 标题:Sulfur-Substituted α-Alkyl Phenethylamines As Selective And Reversible Mao-A Inhibitors: Biological Activities,Comfa Analysis,And Active Site Modeling 作者:Gallardo-Godoy,Alejandra; Et Al 参考文献:Journal Of Medicinal Chemistry 日期:2005 卷标:48(7) 页码:2407-2419]
621-23-8 + 93-61-8 = 830-79-5 反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Diethyl Ether 标题:Alkyl-Oxygen Fission In Carboxylic Esters. Xi. Reactions Of Secondary Alcohols Containing The 2,4,6-Trimethoxyphenyl Radical 作者:Kenyon,J.; Et Al 参考文献:Journal Of The Chemical Society 日期:1952 卷标:4964 页码:4964-9]
621-23-8 = 830-79-5 反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Benzene 标题:Mescaline Analogs. I. 2,4,6-Trialkoxyphenethylmines 作者:Benington,F.; Et Al 参考文献:Journal Of Organic Chemistry 日期:1954 卷标:19 页码:11-16]
40243-91-2 = 830-79-5 反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Vanadium Oxide (V2O5) (Supported On Tio2) Solvents: Acetonitrile; 4 H,30 °C 标题:V2O5@tio2 Catalyzed Green And Selective Oxidation Of Alcohols,Alkylbenzenes And Styrenes To Carbonyls 作者:Upadhyay,Rahul; Et Al 参考文献:Chemcatchem 日期:2021 卷标:13(16) 页码:3594-3600]
61040-78-6 = 830-79-5 反应条件:1.1 Reagents: Potassium Carbonate,Oxygen Catalysts: Palladium Solvents: Toluene; 11 H,90 °C 标题:Palladium Pincer Complex Incorporation Onto The Fe3O4-Entrapped Crosslinked Multilayered Polymer As A High Loaded Nanocatalyst For Oxidation 作者:Zohreh,Nasrin; Et Al 参考文献:Journal Of Molecular Liquids 日期:2018 卷标:266 页码:393-404]
= 830-79-5 [标题:Reaction Conditions 标题:Photosensitized Electron-Transfer Reaction Of 3-Aryl-2-Methyloxaziridine: Direct Deoxygenation From The Isomeric Arylnitrone 作者:Iwano,Yasunori; Et Al 参考文献:Bulletin Of The Chemical Society Of Japan 日期:1994 卷标:67(8) 页码:2348-50]
= 830-79-5 反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone2.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide 标题:New Convenient Synthesis Of 8-C-Methylated Homoisoflavones And Analysis Of Their Structure By Nmr And Tandem Mass Spectrometry 作者:Yadav,Santosh Kumar 参考文献:International Journal Of Organic Chemistry 日期:2021 卷标:11(1) 页码:46-54]
224156-28-9 = 830-79-5 反应条件:1.1 -2.1 Reagents: Phosphorus Oxychloride 标题:The Vilsmeier Reaction Of Fully Conjugated Carbocycles And Heterocycles 作者:Jones,Gurnos; Et Al 参考文献:Organic Reactions (Hoboken 日期:1997 卷标:49]
570-02-5 = 830-79-5 反应条件:1.1 Reagents: Thionyl Chloride; 4 H,Reflux1.2 2 H,Reflux2.1 Reagents: Phosphorus Oxychloride; Cooled; 3 H,Rt2.2 Reagents: Sodium Hydroxide Solvents: Water; Overnight,Neutralized 标题:Synthesis Of Stable Free Radicals As Potential Organic Metals. Synthesis Of Oxygenated Indacene Derivatives. Reactions Of Aromatic Poly(N,N-Dimethylamides) With Electrophiles 作者:Armstrong,Mark Wayne 参考文献:1983]
44205-36-9 = 830-79-5 反应条件:1.1 -2.1 -3.1 Reagents: Phosphorus Oxychloride 标题:The Vilsmeier Reaction Of Fully Conjugated Carbocycles And Heterocycles 作者:Jones,Gurnos; Et Al 参考文献:Organic Reactions (Hoboken 日期:1997 卷标:49]
621-23-8 + 4885-02-3 = 830-79-5 + 591228-81-8 反应条件:1.1 Catalysts: Silver Triflate Solvents: Dichloromethane; -78 °C; 15 Min,0 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; 30 Min,Rt 标题:A Direct And Mild Formylation Method For Substituted Benzenes Utilizing Dichloromethyl Methyl Ether-Silver Trifluoromethanesulfonate 作者:Ohsawa,Kosuke; Et Al 参考文献:Journal Of Organic Chemistry 日期:2013 卷标:78(7) 页码:3438-3444]
32316-92-0 = 830-79-5 + 13250-06-1 反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-κn1,κn1′]Bis[3,5-Diflu... Solvents: Dichloromethane; 12 H,40 °C 标题:Visible-Light-Mediated Late-Stage Sulfonylation Of Boronic Acids Via N-S Bond Activation Of Sulfonamides 作者:Zhen,Jingsong; Et Al 参考文献:Acs Catalysis 日期:2022 卷标:12(3) 页码:1986-1991
2,4,6-三甲氧基苯乙醇置于laccase,2,2,6,6-四甲基哌啶氧化物,Sodium Acetate体系中,用 乙醚 作为反应溶剂,以83 %的收率获得产物2,4,6-三甲氧基苯甲醛 参考文献:白腐蘑菇 Tricholoma Giganteum Aghp 漆酶选择性氧化苯甲醇:Taccabulin A,Taccabulin D 和 Taccabulin E 的全合成 标题:白腐蘑菇 Tricholoma Giganteum Aghp 漆酶选择性氧化苯甲醇:Taccabulin A,Taccabulin D 和 Taccabulin E 的全合成 摘要:使用漆酶将苄醇绿色选择性氧化为相应的醛,由蘑菇tricholoma Giganteum Aghp置于tempo 存在下作为介质在温和和环境友好的反应条件下产生,在 8-24 小时内具有优异的产率(高达 95%).这种方法的适用性已扩展到各种底物和抗癌剂,天然二氢查耳酮 Taccabulin A,Taccabulin D 和 Taccabulin E 的全合成. DOI:10.1016/j.Tet.2022.133114
专利号:US-7951961-B2 优先权日:2006-07-07 标题:Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof 发明人:SIVAKUMAR MEENAKSHI; SHUKLA MANOJ; JADHAV PRAMOD KUMAR; BORHADE AJIT 权利人:PIRAMAL LIFE SCIENCES LTD 摘要:The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer n nwherein Ar has the meaning as indicated in the claims.
专利号:US-9475814-B2 优先权日:2011-10-03 标题:Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof 发明人:HOVEYDA HAMID R; DUTHEUIL GUILLAUME; FRASER GRAEME L; ROY MARIE-ODILE; EL BOUSMAQUI MOHAMED; BATT FREDERIC 权利人:EUROSCREEN SA 摘要:The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.
专利号:US-8710268-B2 优先权日:2007-07-31 标题:Method for the hydrolysis of substituted formylamines into substituted amines 发明人:BOBYLEV MIKHAIL 权利人:BOBYLEV MIKHAIL 摘要:An improved method for the synthesis of substituted formylamines and substituted amines via an accelerated Leuckart reaction. The Leuckart reaction is accelerated by reacting formamide or N-alkylformamide and formic acid with an aldehyde or a ketone at a preferred molar ratio that accelerates the reaction. The improved method is applicable to various substituted aldehydes and ketones, including substituted benzaldehydes. An accelerated method for the hydrolysis of substituted formylamines into substituted amines using acid or base and a solvent at an elevated temperature. The improved method is useful for the accelerated synthesis of agrochemicals and pharmaceuticals such as vanillylamine, amphetamine and its analogs, and formamide fungicides.
专利号:US-8202985-B2 优先权日:2005-10-31 标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H 权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.
专利号:US-7759471-B2 优先权日:2005-10-31 标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H 权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.
专利号:US-2003203915-A1 优先权日:2002-04-05 标题 :Nitric oxide donors, compositions and methods of use related applications 发明人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI 权利人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI 摘要:The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO 2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.
参考标题:Construction Of 2-Substituted-3-Functionalized Benzofurans Via Intramolecular Heck Coupling: Application To Enantioselective Total Synthesis Of Daphnodorin B 作者:Hu Yuan,Kai-Jian Bi,Bo Li,Rong-Cai Yue,Ji Ye,Yun-Heng Shen,Lei Shan,Hui-Zi Jin,Qing-Yan Sun,Wei-Dong Zhang |发布日期:2013.9.20 摘要:A Novel Approach Was Developed For The Synthesis Of 2-Substituted-3-Functionalized Benzofurans, Using An Intramolecular Heck Reaction Which Was Further Applied In The First Enantioselective Total Synthesis Of Daphnodorin B.
合成参考文献
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