CAS: 82038-34-4; Boc-Metyr-Oh

该化合物是一种受保护的氨酸衍生物,通常用于peptide合成和药用化学中."Boc"(乙基-丁基氧碳基)组是氨基功能的保护组,允许有选择的反应,而不会干扰氨基组."N-Me"表示氮原子中存在一个可影响分子的性格和电子特性的甲基组."Tyr"指强酸,一种芳香氨酸,在蛋白结构和功能中起着关键作用.该化合物一般是白色至非白色固体的,在二甲基硫氧化物和乙醇等有机溶剂中溶解,但水中的溶解性较小.其应用延伸到peptides合成,在酸性条件下可以清除该有机物组,从而便利进一步的反应.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号64263-81-6 B°C-N-甲基-O- 苄基-L-酪氨酸 | CAS号112196-59-5 (L)-N-B°C-N-met... | CAS号2130-96-3 B°C-O-苄基-L-酪氨酸 | CAS号1080-06-4 L-酪氨酸甲酯 | CAS号4326-36-7 B°C-L-酪氨酸甲酯 | CAS号60-18-4 L-酪氨酸 | CAS号112196-57-3 O-叔丁基二甲基甲硅烷基-Nt... | CAS号112196-58-4 O-叔丁基二甲基甲硅烷基-N-...

合成工艺路线路线简述

  • 112196-59-5 = 82038-34-4
    反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water
    标题:Studies On The Total Synthesis Of Bouvardin And Deoxybouvardin: Cyclic Hexapeptide Cyclization Studies And Preparation Of Key Partial Structures
    作者:Boger,Dale L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(3) 页码:487-99]

    112196-58-4 = 82038-34-4
    反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 1 H,0 °C1.2 Reagents: Citric Acid Solvents: Water; Ph 4 - 5
    标题:Tertiary-Butoxycarbonyl (Boc) - A Strategic Group For N-Protection/deprotection In The Synthesis Of Various Natural/unnatural N-Unprotected Amino Acid Cyanomethyl Esters
    作者:Karmakar,Ananta; Et Al
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(48) 页码:4267-4271]

    112196-57-3 = 82038-34-4
    反应条件:1.1 Reagents: Methyl Iodide,Sodium Hydride Solvents: Dimethylformamide2.1 Solvents: Acetic Acid,Tetrahydrofuran,Water3.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water
    标题:Studies On The Total Synthesis Of Bouvardin And Deoxybouvardin: Cyclic Hexapeptide Cyclization Studies And Preparation Of Key Partial Structures
    作者:Boger,Dale L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(3) 页码:487-99]

    18162-48-6 + 4326-36-7 = 82038-34-4
    反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide2.1 Reagents: Methyl Iodide,Sodium Hydride Solvents: Dimethylformamide3.1 Solvents: Acetic Acid,Tetrahydrofuran,Water4.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water
    标题:Studies On The Total Synthesis Of Bouvardin And Deoxybouvardin: Cyclic Hexapeptide Cyclization Studies And Preparation Of Key Partial Structures
    作者:Boger,Dale L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(3) 页码:487-99]

    24424-99-5 + 1080-06-4 = 82038-34-4
    反应条件:1.1 Reagents: Triethylamine Solvents: Acetonitrile; 1 H,Rt2.1 Reagents: Imidazole Solvents: Dimethylformamide; 0 °C; Overnight,Rt3.1 Reagents: Sodium Hydride; 0 °C; 2 H,0 °C3.2 Solvents: Water4.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 1 H,0 °C4.2 Reagents: Citric Acid Solvents: Water; Ph 4 - 5
    标题:Tertiary-Butoxycarbonyl (Boc) - A Strategic Group For N-Protection/deprotection In The Synthesis Of Various Natural/unnatural N-Unprotected Amino Acid Cyanomethyl Esters
    作者:Karmakar,Ananta; Et Al
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(48) 页码:4267-4271]

    64263-81-6 = 82038-34-4
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
    标题:Synthesis Of The Cyclodepsipeptide Nordidemnin B,A Cytotoxic Minor Product Isolated From The Sea Tunicate Trididemnum Cyanophorum
    作者:Jouin,Patrick; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(3) 页码:617-27]

    112196-58-4 = 82038-34-4
    反应条件:1.1 Solvents: Acetic Acid,Tetrahydrofuran,Water2.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water
    标题:Studies On The Total Synthesis Of Bouvardin And Deoxybouvardin: Cyclic Hexapeptide Cyclization Studies And Preparation Of Key Partial Structures
    作者:Boger,Dale L.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(3) 页码:487-99]

    112196-57-3 = 82038-34-4
    反应条件:1.1 Reagents: Sodium Hydride; 0 °C; 2 H,0 °C1.2 Solvents: Water2.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 1 H,0 °C2.2 Reagents: Citric Acid Solvents: Water; Ph 4 - 5
    标题:Tertiary-Butoxycarbonyl (Boc) - A Strategic Group For N-Protection/deprotection In The Synthesis Of Various Natural/unnatural N-Unprotected Amino Acid Cyanomethyl Esters
    作者:Karmakar,Ananta; Et Al
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(48) 页码:4267-4271]

    18162-48-6 + 4326-36-7 = 82038-34-4
    反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide; 0 °C; Overnight,Rt2.1 Reagents: Sodium Hydride; 0 °C; 2 H,0 °C2.2 Solvents: Water3.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 1 H,0 °C3.2 Reagents: Citric Acid Solvents: Water; Ph 4 - 5
    标题:Tertiary-Butoxycarbonyl (Boc) - A Strategic Group For N-Protection/deprotection In The Synthesis Of Various Natural/unnatural N-Unprotected Amino Acid Cyanomethyl Esters
    作者:Karmakar,Ananta; Et Al
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(48) 页码:4267-4271]

    60-18-4 = 82038-34-4
    反应条件:1.1 Reagents: Thionyl Chloride; 0 °C; Overnight,Rt2.1 Reagents: Triethylamine Solvents: Acetonitrile; 1 H,Rt3.1 Reagents: Imidazole Solvents: Dimethylformamide; 0 °C; Overnight,Rt4.1 Reagents: Sodium Hydride; 0 °C; 2 H,0 °C4.2 Solvents: Water5.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 1 H,0 °C5.2 Reagents: Citric Acid Solvents: Water; Ph 4 - 5
    标题:Tertiary-Butoxycarbonyl (Boc) - A Strategic Group For N-Protection/deprotection In The Synthesis Of Various Natural/unnatural N-Unprotected Amino Acid Cyanomethyl Esters
    作者:Karmakar,Ananta; Et Al
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(48) 页码:4267-4271
Boc-O-苄基-L-酪氨酸置于palladium On Activated Charcoal 氢气,Sodium Hydride体系中,用 四氢呋喃,1,4-二氧六环,溶剂黄146,Paraffin 作为反应溶剂,化学反应 77.0H,反应生成 Boc-N-甲基-L-酪氨酸
参考文献:Bates,Robert B.; Gin,Susan L.; Hassen,Mark A.,Heterocycles,1984,Vol. 22,# 4,P. 785-790
标题:Bates,Robert B.; Gin,Susan L.; Hassen,Mark A.,Heterocycles,1984,Vol. 22,# 4,P. 785-790

海关参考信息

专利信息


专利号:US-2014275533-A1
优先权日:2013-03-15
标题:Methods of Manufacture and Synthesis of Amino Acid Linking Groups Conjugated To Compounds Used For Targeted Imaging of Tumors

专利号:CN-120192280-A
优先权日:2025-02-18
标 题:Synthesis of amino acid derivatives containing 1,3, 4-oxadiazole thioether and application of amino acid derivatives in resisting plant bacterial diseases

其他信息查阅

成都诺恩克生物科技有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证，请用户仔细辨别，谨慎交易。
数据来源于公开网络搜索，平台未作核实，请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.lavemc.com/
电话: 28-86066080 18280039962👤
📞成都诺恩克生物科技有限公司 ⚠️参考联系方式

销售电话:28-86066080 18280039962
邮箱：sales@lavemc.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Tertiary-Butoxycarbonyl (Boc) - A Strategic Group For N-Protection/deprotection In The Synthesis Of Various Natural/unnatural N-Unprotected Aminoacid Cyanomethyl Esters
作者:Ananta Karmakar,Mushkin Basha,G.T. Venkatesh Babu,Murali Botlagunta,Noormohamed Abdul Malik,Richard Rampulla,Arvind Mathur,Arun Kumar Gupta |发布日期:2018.11
摘要:Available 4M Hcl In 1,4-Dioxane Solution (2-4 Equiv); Acetonitrile, 0 °C, 2-4 H Was A Suitable Condition. This Condition Was Generalized And Successfully Applied To A Variety Of Alkyl, Alkynyl, Aryl, Heteroaryl, Benzyl, Azido, Spiro Amino Acid Cyanomethylesters Irrespective Of The Nature Of The Amine (Primary Or Secondary) And The Distance Between The Amine And Ester Group To Achieve Final Deprotected

合成参考文献

合成方法参考DOI号:10.1021/jo00238a005
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知