CAS: 6809-52-5; 6,10,14,18-Tetramethylnonadeca-5,9,13,17-Tetraen-2-One

该化合物是能够加强肌肉保护物质的生产,从而协助预防和治疗胃溃疡;Teprenone具有抗肺炎的特性,并研究其在各种肠胃紊乱中的潜在好处;该化合物一般是口服的,在胃肠道中吸收良好;其行动机制包括刺激肌肉细胞扩散和将血液流动增加至胃肌肉.此外,对Teprenone的潜在...

结构式图片

上下游产品

CAS号71668-81-0 (4E,8E,12E)-eth... | CAS号1206897-24-6 (6E,10E)-3,7,11... | CAS号1694-31-1 乙酰乙酸叔丁酯 | CAS号1113-21-9 香叶基芳樟醇 | CAS号72324-39-1 5-乙酰基-2,2-二甲基-1... | CAS号186581-53-3 重氮甲烷 | CAS号1033756-53-4 3,5-dibromo-4-(... | CAS号105-45-3 乙酰乙酸甲酯 | CAS号106-28-5 金合欢醇 | CAS号1182-68-9 Menaquinone 5

合成工艺路线路线简述

  • 合成目标产物 Teprenone 主要起始原料 Ethyl (4E,8E,12E)-2-Acetyl-5,9,13,17-Tetramethyloctadeca-4,8,12,16-Tetraenoate
  • (文献来源)合成步骤主要原料 Ethyl (4E,8E,12E)-2-Acetyl-5,9,13,17-Tetramethyloctadeca-4,8,12,16-Tetraenoate
Geranyldehydrolinaool置于lindlar'S Catalyst 喹啉,氢气体系中,用 环己烷 作为反应溶剂,化学反应生成 替普瑞酮
参考文献:Weichet,J. Et Al.,Collection Of Czechoslovak Chemical Communications,1960,Vol. 25,P. 1914-1921
标题:Weichet,J. Et Al.,Collection Of Czechoslovak Chemical Communications,1960,Vol. 25,P. 1914-1921

海关参考信息

专利信息


专利号:US-9981935-B2
优先权日:2013-07-05
标 题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of acids
发明人:MEDLOCK JONATHAN ALAN; LETINOIS ULLA; NETSCHER THOMAS; BONRATH WERNER
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.

专利号:US-9815809-B2
优先权日:2013-07-05
标题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols
发明人:LETINOIS ULLA; NETSCHER THOMAS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.

专利号:US-9809565-B2
优先权日:2013-07-05
标 题 :Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of ureas or thioureas
发明人:LETINOIS ULLA; NETSCHER THOMAS; ACKERMANN STEPHAN
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.

专利号:US-2004249219-A1
优先权日:2000-07-05
标题 :Method of making teprenone
发明人:SAUCY GABRIEL G
摘要:The invention is directed to an efficient and economical method of making teprenone. Teprenone is synthesized by converting geranylgeraniol to teprenone by a novel route. The method of synthesis can begin with geranylgeraniol obtained from a biological source such as fermentation of a microorganism capable of producing geranylgeranyl or enzymatic synthesis in a cell free system to produce predominantly the 5E isomer of teprenone. The chemical synthesis proceeds with retention of configuration such that the teprenone produced has the isomeric configuration of the geranylgeraniol starting material.

专利号:WO-2014018862-A1
优先权日:2012-07-27
标 题 :Pharmaceutical compositions comprising a heat shock protein inhibitor and a; purine de novo synthesis inhibitor for treating rheumatoid arthritis or cancer
发明人:FANG YE
权利人:CORNING INC; FANG YE
摘要:A pharmaceutical composition including an effective amount of the combination of: an heat shock protein (HSP) inhibitor, and a purine de novo biosynthesis inhibitor, or a pharmaceutically acceptable salt thereof. Also disclosed is a method of treating rheumatoid arthritis or cancer including administering an effective amount of the above mentioned pharmaceutical composition to a patient in need of such treatment, as defined herein.

专利号:US-3939202-A
优先权日:1973-01-31
标题:Process for preparing polyene compounds
发明人:MATSUI MASANAO; KITAMURA SEIICHI; MORIOKA MASAHIRO
权利人:TEIKOKU CHEM IND CO LTD
摘要:Polyene compounds of the formula: ##EQU1## wherein R' is protected or unprotected hydroxyl or a group of the formula: ##EQU2## (in which R' and R'' are each carboxyl or a group convertible into carboxyl on hydrolysis), m is a positive integer and n is 0 or a positive integer, which are useful as intermediates in the synthesis of coenzyme Q, can be produced advantageously through a step for the dehydration of a compound of the formula: ##EQU3## wherein R', m and n are each as defined above.
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合成参考文献


参考文献:10.1016/j.ejmech.2017.07.043
摘要:Maruta H, Ahn M. From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. European Journal of Medicinal Chemistry. 2017 Dec;142():229–43. doi: 10.1016/j.ejmech.2017.07.043.
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