CAS: 61360-94-9; 8-((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)-5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4H-Chromen-4-One

上下游产品

牡荆素 Vitexin 3681-93-4
尿苷(5')二氢二磷酰(1)-Alpha-D-葡萄糖 Udp-Glucose 133-89-1

📜尿苷(5')二氢二磷酰(1)-Alpha-D-葡萄糖,牡荆素置于pet28A-C-Glycosyltransferase Tccgt1 Protein,2''-O-Galactosyltransferase Tcogt4 From Trollius Chinensis P361W Mutant体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 9.0H,以62.8%的收率获得产物牡荆素2"-葡萄糖苷
参考文献:Characterization Of A Highly Selective 2''-O-Galactosyltransferase From Trollius Chinensis And Structure-Guided Engineering For Improving Udp-Glucose Selectivity
标题:Characterization Of A Highly Selective 2''-O-Galactosyltransferase From Trollius Chinensis And Structure-Guided Engineering For Improving Udp-Glucose Selectivity
摘要:
DOI:10.1021/acs.Orglett.1C02581

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.