专利号:US-4814506-A 优先权日:1986-08-26 标题:Process for preparing 3 halogeno-2-hydroxypropyltrimethylammonium halide 发明人:KATAYAMA KAZUHIKO; HAMAGUCHI SHIGEKI; KOGAME YOSHIKAZU; OHASHI TAKEHISA; WATANABE KIYOSHI 权利人:KANEGAFUCHI CHEMICAL IND 摘要:A process for preparing 3-halogeno-2-hydroxy-propyltrimethylammonium halide or especially one having the (S)-configuration, which comprises reacting 2,3-dihydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is obtained by reacting (R)-3-halogeno-1,2-propanediol with trimethylamine, with a halogenating reagent. According to the present invention, 3-halogeno-2-hydroxypropyltrimethylammonium halide or one having the (S)-configuration, which is a useful intermediate for the synthesis of carnitine or especially (l)-carnitine, can be obtained economically, efficiently and easily.
摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/Q_schafer832.pdf