CAS: 50533-97-6; N,N-Dimethylpiperidin-4-Amine

相似化合物

4876-59-9 108612-54-0 553672-39-2

上下游产品

CAS号506-59-2 盐酸二甲胺 | CAS号79099-07-3 1-B°C-4-哌啶酮 | CAS号64168-08-7 1-苄基-4-(二甲氨基)哌啶 | CAS号1122-58-3 4-二甲氨基吡啶 | CAS号211247-60-8 N,N-二甲基-1-(4-硝基... | CAS号211247-62-0 1-(4-氨基苯基)-N,N-... | CAS号1197160-78-3 吉达利塞 | CAS号1122-58-3 4-二甲氨基吡啶

4-二甲氨基吡啶置于cp*rh(2-(2-Pyridyl)Phenyl)H,氢气体系中,用 Neat (No Solvent) 作为反应溶剂,100.0 °C,3.65 Mpa 条件下,反应 48.0H,以99%的收率获得产物4-二甲氨基哌啶
参考文献:使用铑预催化剂氢化 N-杂芳烃:还原消除导致多金属簇的形成
标题:使用铑预催化剂氢化 N-杂芳烃:还原消除导致多金属簇的形成
摘要:描述了一种用于氢化 N-杂芳烃的铑催化方法.使用有机金属预催化剂 (η5-C5Me5)Rh(Nc)H(nc = 2-苯基吡啶基 (Ppy) 或苯并[h]喹啉基(bq)).此外,聚芳族n-杂芳烃的氢化表现出不寻常的化学选择性.对催化剂活化的研究表明,(η5-C5Me5)Rh(Bq)H 的光化学或热活化诱导 C(Sp2)-H 还原消除并反应生成双金属配合物 [(η5-C5Me5)Rh(µ2,η2-Bq) Rh(η5-C5Me5)H].在 H2 存在下,(η5-C5Me5)Rh(Nc)H 前体和 [(η5-C5Me5)Rh(μ2,η2-Bq)Rh(η5-C5Me5)H] 均转化为五金属氢化铑簇,(η5-C5Me5)4Rh5H7,其结构由核磁共振光谱,X射线和中子衍射确定.用每种分离的铑配合物进行吡啶氢化的动力学研究,以鉴定催化相关物质.数据与由未观测到的多金属簇促进的氢化催化最一致,其中形成 (η5-C5Me5)4Rh5H7
DOI:10.1021/jacs.9B09540

专利信息

专利号:US-6413957-B1
优先权日:1998-04-21
标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SUIBB PHARMA COM
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-7250435-B2
优先权日:1999-10-20
标 题:Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n nthat are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.n n This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:WO-2019013789-A1
优先权日:2017-07-12
标 题 :ANTIMICROBIAL COMPOUNDS
发明人：REDDY HARIPRASADA R KANNA; SEBAHAR PAUL R; SERRANO CATHERINE M; LOOPER RYAN E
权利人:CURZA GLOBAL LLC; THE UNIV OF UTAH RESEARCH FOUNDATION
摘要:The invention relates to compounds of formula I or their pharmaceutically acceptable salts. The compounds of formula I are antimicrobial agents which inhibit, for example, Mycobacterium tuberculosis (Mtb) H37Ra. The compounds of formula I also have anti-tuberculous activity, exhibit limited cytotoxicity and inhibit protein synthesis. The invention also relates to methods of making compounds of formula I, as well as methods of using compounds of formula I for the treatment of bacterial infections, particularly tuberculosis.

专利号:US-6407103-B2
优先权日:1998-04-21
标 题:Indeno [1,2-c] pyrazol-4-ones and their uses
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:DE-102005032795-A1
优先权日:2005-07-14
标 题 :Synthesis of porous manganese oxides

专利号:US-6593356-B2
优先权日:1999-10-20
标 题 :Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID; CARINI DAVID; DIMEO SUSAN; VIDWANS ANUP; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.