CAS: 38953-29-6; 2-Chloro-4-Fluoropyrimidine

相似化合物

2802-62-2 2802-61-1 38953-30-9

📜2,4-二氯嘧啶置于1,8-Bis(Dimethylamino)Naphthalene (Hydrogen Fluoride)体系中,化学反应 48.0H,以40%的收率获得2-氯-4-氟嘧啶
参考文献:通过"质子海绵"-三乙胺三(氟化氢)体系促进的氯二嗪和氯吡啶的卤素交换进行选择性氟化
标题:通过"质子海绵"-三乙胺三(氟化氢)体系促进的氯二嗪和氯吡啶的卤素交换进行选择性氟化
摘要:"质子海绵"-三乙胺三(氟化氢)混合物提供了一种温和而有效的氟化试剂,可通过卤素交换将氟原子选择性地引入氯二嗪和氯硝基吡啶系列中.
Doi:10.1016/s0040-4020(00)01060-7

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-7216975-B2
优先权日:2003-07-15
标 题 :Method for preparing the reactive tinting compound and the tinted contact lens
发明人：HONG SHINN-GWO
权利人:HONG SHINN-GWO
摘要:A method for preparing the tinted contact lens with the covalently bonded novel reactive tinting compound is disclosed. The reactive tinting compound with mono vinyl functionality is prepared by reacting the reactive dye with a hydrophilic monomer containing both pendent hydroxyl and vinyl groups under an alkaline condition. The water soluble reactive dyes containing either difluoro-chloropyrimidine or β-sulphatoethylsulphone reactive groups are used for synthesis of the reactive tinting dye. The lens forming materials are photo-polymerized in the presence of the reactive tinting compound to prepare a tinted contact lens. The reactive tinting compound is copolymerized with the lens forming monomers in a single photo-polymerization step that requires no subsequently alkaline soaking or developing step as used in the prior art. In addition, the covalently bonded dye is stable and durable in the lens and does not fade or leach out after multiple high-pressure thermal sterilizations.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries