CAS: 372963-50-3; (6-Methylpyridin-2-yl)Boronic Acid

该化合物是一种有机体化合物,其特点是附于一个丙烯环上的碳酸功能组;该化合物的特点是,在对丙烯的六处位置上有一个甲基组,影响其反应性和溶解性;该化合物一般是白色的白色和白色的固体,在水和酒精等极地溶剂中溶解,使其在各种化学反应中有用;该乙烯酸组因其有能力与二醇形成可逆的共价结合而闻名,这在诸如有机合成中铃木混合反应等应用中非常重要;此外,该化合物可作为制药和农用化学品开发的建筑块;其再活动可由甲基组的存在加以调节,这可能会影响立心障碍和电子特性.

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1096689-44-9 2819702-45-7 2819702-42-4

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2-bromo-6-methylpyridine

合成工艺路线路线简述

    📜2-溴-6-甲基吡啶置于异丙基氯化镁,三(三甲代甲硅烷基)硼酸盐,盐酸体系中,用 四氢呋喃 作为反应溶剂,化学反应 26.0H,以72%的收率获得产物6-甲基吡啶-2-硼酸
    参考文献:Improved Synthesis Of Azaheteroarylboronic Acids Usingtris-Trimethylsilylborate Under Mild Conditions
    标题:Improved Synthesis Of Azaheteroarylboronic Acids Usingtris-Trimethylsilylborate Under Mild Conditions
    摘要:A New Family Of Azaheteroarylboronic Acids Was Synthesized With Good Yields (70% To 75%). The Proposed Strategy Utilizes An Improved Transmetalation Reaction From Grignard Azine Reagents And Tris-Trimethylsilylborate,Little. Used Until Now.
    DOI:10.1081/scc-120016325

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    专利信息


    专利号:US-8207337-B2
    优先权日:2007-01-29
    标 题:Reagent for organic synthesis reaction containing organic triol borate salt
    发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
    权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
    摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

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    合成参考文献

    参考DOI号:10.1081/SCC-120016325
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