CAS: 350-81-2; N-(Chloroacetyl)-3-Fluoroaniline

该化合物是一种氟乙酰衍生物,可应用于制药和农用化学研究,其主要结构特征包括一个氯乙酰集团和一个3-氟苯基混合物,可增强反应性和潜在生物活性.该化合物是有机合成的多种中间体,特别是在开发新型的氨基化合物方面.其卤化结构允许选择性的功能化,有助于交叉反应和热循环形成.苯基环的氟代用可影响代谢稳定性和生物活性分子的结合性.该化合物通常在受控制的条件下处理,原因是其活性氯乙酰基化合物组,在合成和储存期间需要适当的安全措施.

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CAS号372-19-0 3-氟苯胺 | CAS号79-04-9 氯乙酰氯

合成工艺路线路线简述

    3-氟苯胺 反应生成 N-(氯乙酰)-3-氟苯胺
    参考文献:Acetamides And Benzamides That Are Useful In Treating Sexual Dysfunction
    标题:Acetamides And Benzamides That Are Useful In Treating Sexual Dysfunction
    摘要:本发明涉及使用式(I)的化合物治疗性功能障碍,以及含有式(I)化合物的组合物用于治疗性功能障碍.

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    专利信息


    专利号:WO-2021038419-A1
    优先权日:2019-08-23
    标题 :Kinase inhibitors and methods of synthesis and treatment
    发明人:ZAVORONKOVS ALEKSANDRS; IVANENKOV YAN; POLYKOVSKIY DANIIL; ALIPER ALEKSANDR
    权利人:INSILICO MEDICINE IP LTD
    摘要:Compounds that function as kinase inhibitors are provided. The kinase inhibitors can have any structure of the formulae provided herein, such as shown for Compounds 1-4. A pharmaceutical composition can include: the compound of one of the embodiments; and a pharmaceutically acceptable carrier having the compound. A method of inhibiting a kinase can include: providing the compound of one of the embodiments described herein to the kinase such that the kinase is inhibited. The methods can include inhibiting DDR1 and/or DDR2, and thereby providing a modulation or decrease in the activity of DDR1 and/or DDR2. This decrease in DDR1 and/or DDR2 activity can be used as therapy to treat conditions related to DDR1 and/or DDR2 activity, such as fibrosis, cancer, and others.

    专利号:US-10954197-B2
    优先权日:2017-03-08
    标 题 :Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer
    发明人:YOGEESWARI PERUMAL
    权利人:YOGEES BIOINNOVATIONS PRIVATE LTD
    摘要:Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer are provided. More particularly, the embodiments relate to the design and synthesis of inhibitors of Cathepsin D, which exhibits antiproliferative activity and also inhibits angiogenesis. Also provided are compositions thereof for treating breast cancer.

    专利号:CN-104230762-B
    优先权日:2014-08-28
    标题:A kind of benzenesulfonamides of phosphinylidyne-containing amine group and Synthesis and applications thereof

    专利号:RU-2400471-C1
    优先权日:2009-04-30
    标 题:N-substituted derivatives of oxamic acid thiohydrazides, synthesis method and use thereof
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    合成参考文献


    参考文献:10.1107/s2056989015007240
    摘要:Sreenivasa S, Suchetan PA, Naveen S, Lokanath NK, Srivishnu KS. Crystal structure of 2-chloro-N-(3-fluoro-phen-yl)acetamide. Acta Crystallogr E Crystallogr Commun. 2015 May 01;71(Pt 5):o315.
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