CAS: 3337-71-1; Asulam

该化合物是一种系统性除草剂,主要用于控制不同农业环境中的杂草,属于灭菌类,其功能包括抑制酶乙酰胺合成酶,这对植物中分链氨基酸合成至关重要;Asulam通常用于马铃薯和某些谷物等作物,其有效针对的作物包括一系列大叶麻和草杂草;该物质的特点是其对哺乳动物的毒性相对较低,使其在综合虫害管理中成为首选;然而,必须小心处理气泡,因为它可能对水生生物构成风险,并可能对其使用有具体的环境条例;水中的溶性以及各种条件下的稳定性有助于其作为除草剂的效力,但使用者必须遵守所建议的应用率和安全准则,以尽量减少对非目标物种和生态系统的潜在不利影响.

英文名称Asulam
中文名称磺草灵
IUPAC名称methyl ((4-aminophenyl)sulfonyl)carbamate
其它别名[(4-Aminophenyl)sulfonyl]carbamic acid methyl ester; Methyl [(4-aminophenyl)sulfonyl]carbamate; Methyl sulfanilylcarbamate; Asilan; Asulox; Jonnix
CAS编号3337-71-1
MFCD编号:MFCD00055534
EINECS号:222-077-1
FDA UNII编号:0Y5ASM7P5S
分子式:C8H10N2O4S
分子量:230.24
产品CID: 1329270
同类组份化合物CAS3337-71-1 (free base)2302-17-2 (sodium)14089-43-1 (potassium)
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: VGPYEHKOIGNJKV-UHFFFAOYSA-N
InChI=1S/C8H10N2O4S/c1-14-8(11)10-15(12,13)7-4-2-6(9)3-5-7/h2-5H,9H2,1H3,(H,10,11)…
计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数2.0

物理性质

熔点142-144 °C
沸点142-144 °C (分解)
闪点°C
密度1.418g/cm3
pKa:4.82(at 25°C)
PSA:98.49
LogP:0.3135
折射率1.5690 (estimate)
蒸汽压1.39X10-6 mm Hg at 25 °C (est)
溶解性可溶于DMSO(少许),甲醇(少许)
敏感性常温常压下稳定，无色结晶。
外观形态固体-粉末
储存条件常温，避光，通风干燥环境处，密封保存保存
产品应用细胞分裂抑制剂.具有内吸性,可以通过植物的叶茎和根部吸收.可以选择性防治菠菜,苜蓿,一些观赏植物,甘蔗,香蕉,咖啡,茶,可可,椰子,橡胶胶等作物上的一年生和多年生禾本科杂草和阔叶杂草.还可以防治亚麻上的野燕麦,草地,果树,灌木和非耕作区的酸模,草皮,非耕作区和森林的欧洲蕨.施药剂量可根据作物不同为1-10kg/ha
性质描述纯品为无色结晶体;熔点142-144°C(分解).溶解度(20-25°C);水中4g/l;丙酮中300/l;烃,氯化烃中<20g/l;甲醇中290g/l.其亚氨基是酸性的(pka4.82),形成水溶性盐.沸水中>/6h内稳定,Ph8.5(室温下)稳定性>4年.质量标准:外观微黄色晶体粉末微黄色晶体粉末含量≥9596．7水分≤1．00．2丙酮不溶物(m/m)≤1．00．3

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
警示词Warning(警告)
危险描述H302 |吞咽有害.
防范说明P264-P270-P330-P501
UN编号NONH for all modes of transport
危险品标志Xn: Harmful;
安全声明IDENTIFICATION AND USE: Asulam is a herbicide used for weed control. Asulam is formulated into and applied as the asulam sodium salt. HUMAN STUDIES: In vitro cytogenetics assay in human lymphocytes were negative for asulam. ANIMAL STUDIES: Application of technical asulam to rabbit eyes produced mild chemosis, irritation, and redness which cleared by day seven posttreatment. Asulam was not an irritant in a primary skin irritation study in rabbits. It did not cause dermal sensitization in guinea pigs. In a six-month feeding study of asulam in beagle dogs doses of asulam at 300 mg/kg/day and 1,500 mg/kg/day were associated with reductions in food consumption, body weight gain, emesis, diarrhea, and reductions in red blood cells, hemoglobin and packed cell volume. There were also elevated thyroid and kidney weights and reduced testicular weights. In a two-year carcinogenicity study mice, asulam was administered in the diet at 0, 500, 5,000 or 50,000 ppm. There was no increase in the incidence of any tumors. A two-year combined chronic feeding/carcinogenicity study was conducted using rats. Hyperplastic changes were observed in the adrenal medulla and in thyroid follicular cells of males at the doses of 180 and 953 mg/kg/day. There was a statistically significant increase in thyroid gland c-cell carcinomas and in adenomas and carcinomas combined in both the low- and mid-dose males. There was a statistically-significant increase in benign adrenal medullary pheochromocytomas at the high dose in males. No teratogenic effects were produced by asulam in either rats or rabbits. The Ames Assay which is used to detect gene mutation with Salmonella typhimurium was negative. Mutagenicity assays which detect structural chromosome aberrations included the dominant lethal test in mice and were negative for asulam. ECOTOXICITY STUDIES: When tested in bobwhite quail (Colinus virginianus) dietary study, asulam had no effect on food consumption, body weight, or cumulative mortality, and no signs of toxicity were seen during the 28-day feeding period. Similarly, the chemical had no effect on egg production, fertility, or hatchability of fertile eggs, or on abnormalities in the F1 generation. | Asulam is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase. Because of its essential function, chemicals that interfere with the action of acetylcholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death. Nerve gases and many substances used in insecticides have been shown to act by binding a serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate), and a terminal oxygen. | Asulam, sodium salt is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase. Because of its essential function, chemicals that interfere with the action of acetylcholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death. Nerve gases and many substances used in insecticides have been shown to act by binding a serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate), and a terminal oxygen.
危险类别码R22
WGK Germany3

欧盟法规

ECHA物质ECHA物质OtherC&L通报REACH预注册

上下游产品

CAS号79-22-1 氯甲酸甲酯

合成工艺路线路线简述

氯甲酸甲酯,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇体系中,化学反应生成磺草灵
参考文献:Ch222077
标题:Ch222077

海关参考信息

2912110000-甲醛
2915110000-甲酸
2909199090-其他醚及其衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2024256370-A1
优先权日:2023-06-13
标题 :Synthesis of glufosinate using an amidase-based process
发明人：ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

专利号:US-2025120400-A1
优先权日:2021-12-10
标题:Synthesis of glufosinate using a hydantoinase-based process
发明人：DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

专利号:US-11919928-B2
优先权日:2016-03-16
标题 :Method for producing dihydrotentoxin
发明人：KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:KUMIAI CHEMICAL INDUSTRY CO
摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.

专利号:ES-2717283-T3
优先权日:2012-07-24
标题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids

其他信息查阅

河北润田化工有限公司

网址: http://www.richlandchem.com
企业联系电话：86-311-89912746👤
地址:石家庄体育北大街睿和中心2203室

⚠️ 未注册 · 未认证企业

备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

黑龙江邦普生物科技有限公司

网址: http://www.bumperbio.com/
企业联系电话：0459-6336777;15205106099;15061612816👤
地址:黑龙江省大庆市高新区兴化园区建化东路14号

⚠️ 未注册 · 未认证企业

山东侨昌化学有限公司

网址: http://www.qiaochang.com
电话: 021-62570179👤

⚠️ 未注册 · 未认证企业

备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

盐城科拉姆化工有限公司

网址: http://www.climbchem.com
企业联系电话：0515-83073788👤
地址:江苏建湖县御景e学城1号电梯五楼

⚠️ 未注册 · 未认证企业

第 1 / 1 页

现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

1: Mahaboob Basha D, Venkata Reddy G, Gopi Krishna Y, Kumara Swamy BE, Vijay R. Identification and Characterization of Asulam Impurities in Self Made Bulk Batch Synthesis and Quantification by RP-HPLC Method. J AOAC Int. 2018 Apr 19. doi: 10.5740/jaoacint.17-0316. [Epub ahead of print] doi: 10.1016/j.bios.2018.03.038. Epub 2018 Mar 17. doi: 10.1016/j.jenvman.2017.11.013. Epub 2017 Nov 14. doi: 10.1016/j.watres.2016.11.048. Epub 2016 Nov 22. doi: 10.1002/jcc.23805. Epub 2015 Jan 6. doi: 10.1002/elps.201400311. doi: 10.1128/AEM.00911-13. Epub 2013 Jul 8.
8: Giussani A, Pou-Amérigo R, Serrano-Andrés L, Freire-Corbacho A, Martínez-García C, Fernández P MI, Sarakha M, Canle L M, Santaballa JA. Combined theoretical and experimental study of the photophysics of asulam. J Phys Chem A. 2013 Mar 14;117(10):2125-37. doi: 10.1021/jp311932z. Epub 2013 Feb 27. doi: 10.1002/jssc.200900036. doi: 10.1002/bio.1137. doi: 10.1002/elps.200800699. doi: 10.1002/ps.1738. Review. doi: 10.1016/j.talanta.2005.12.014. Epub 2006 Jan 10. doi: 10.1094/PHYTO.1998.88.6.530. doi: 10.1016/j.talanta.2008.06.025. Epub 2008 Jun 27. doi: 10.1016/j.talanta.2007.07.034. Epub 2007 Aug 7. Epub 2007 Sep 28. Epub 2007 Mar 20.

合成参考文献

摘要:Agricultural Chemicals, Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision, 2(90), 1977
摘要:Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan., 15(497), 1990
摘要:Agrochemicals Handbook, with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86, A021(1983)
摘要:US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.11. Nov, 2012. Available from, as of July 5, 2018:
摘要:USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Asulam p.5 EPA 738-R-95-024 (September 1995). Available from, as of June 25, 2018: https://www.epa.gov/pesticides/reregistration/status.htm

📝 需求与反馈

📲 手机号 / 邮箱 *

✏️ 问题内容 *

尽可能描述清楚需求与问题信息

CAS: 3337-71-1; Asulam

物理性质

MSDS等安全信息

欧盟法规

上下游产品

合成工艺路线路线简述

海关参考信息

专利信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

主要参考文献

合成参考文献

通知